Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 20/20 | 0.73 |
| ▸ | SLC6A3 known ✓ | Q01959 | 11/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 18/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL4477821 | 1.00 | SLC6A2 (0.73) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4493203 | 0.92 | SLC6A2 (0.86) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4486181 | 0.92 | SLC6A2 (0.86) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5994904 | 0.85 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3 | |
| Fumaric Acid SCHEMBL5996292 | 0.84 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3 | |
| Fumaric Acid SCHEMBL5996295 | 0.84 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3 | |
| Cadaverine Tartrate SCHEMBL4490409 | 0.82 | SLC6A4 (0.65) | SLC6A2SLC6A4SLC6A3 | |
| Cadaverine Tartrate SCHEMBL4489190 | 0.81 | SLC6A2 (0.60) | SLC6A2SLC6A4SLC6A3 | |
| Cadaverine Tartrate SCHEMBL4490344 | 0.81 | SLC6A4 (0.58) | SLC6A2SLC6A4SLC6A3 | |
| Cadaverine Tartrate SCHEMBL4480383 | 0.81 | SLC6A4 (0.58) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7619096-B2 | 3-Aminopyrrolidines as inhibitors of monoamine uptake | ELI LILLY AND COMPANY (US) | 2009-11-17 | — | — | US | disclosed |
| EP-1638934-B1 | 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | LILLY CO ELI (US) | 2008-01-09 | — | — | EP | disclosed |