Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TYR | P14679 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.44 |
| ▸ | CLK1 | P49759 | 3/20 | 0.44 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13712184 | 0.83 | MEN1 (0.49) | MEN1KMT2ARAB9AKDM4EALDH1A1 | |
| SCHEMBL4470131 | 0.83 | MEN1 (0.49) | MEN1KMT2ARAB9AKDM4EALDH1A1 | |
| SCHEMBL1516690 | 0.83 | PDPK1 (0.57) | MEN1KMT2ARAB9AKDM4EALDH1A1 | |
| SCHEMBL4475628 | 0.83 | MEN1 (0.52) | MEN1KMT2ARAB9AKDM4EALDH1A1 | |
| Bromide SCHEMBL1516571 | 0.82 | PDPK1 (0.56) | MEN1KMT2ARAB9AKDM4EALDH1A1 | |
| SCHEMBL15500802 | 0.79 | CDK8 (0.64) | MEN1KMT2ARAB9AKDM4EALDH1A1 | |
| SCHEMBL4474062 | 0.74 | PDPK1 (0.63) | MEN1KMT2ARAB9AKDM4EALDH1A1 | |
| SCHEMBL1516783 | 0.74 | MAP3K11 (0.71) | MEN1KMT2ACYP3A4ROCK1DYRK1A | |
| SCHEMBL8175861 | 0.74 | CLK1 (0.46) | MEN1KMT2ARAB9AKDM4EALDH1A1 | |
| SCHEMBL13887926 | 0.72 | ROCK1 (0.74) | CYP3A4ROCK1DYRK1ACCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514448-B2 | Azaindoles useful as inhibitors of rock and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-04-07 | — | — | US | disclosed |
| US-7514448-B2 | Azaindoles useful as inhibitors of rock and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-04-07 | — | — | US | disclosed |
| US-7514448-B2 | Azaindoles useful as inhibitors of rock and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-04-07 | — | — | US | disclosed |
| CN-101014597-A | Azaindoles useful as inhibitors of rock and other protein kinases | VERTEX PHARMA (US) | 2007-08-08 | — | — | CN | disclosed |
| US-20060003968-A1 | Azaindoles useful as inhibitors of rock and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060003968-A1 | Azaindoles useful as inhibitors of rock and other protein kinases | ROCK2, ROCK1, TNK2 | MEN1 875/4885KMT2A 1037/4885RAB9A 907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.