Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.52 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | STAT1 | P42224 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | KPNA2 | P52292 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4482332 | 0.84 | MAPT (0.41) | ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13757487 | 0.83 | MEN1 (0.51) | ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3661525 | 0.82 | SMN1; SMN2 (0.58) | ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8471736 | 0.81 | MEN1 (0.47) | ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15729859 | 0.80 | NPC1 (0.57) | ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4714412 | 0.80 | SMN1; SMN2 (0.54) | ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4474644 | 0.78 | NPY5R (0.44) | ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28614010 | 0.77 | MAPT (0.51) | ALDH1A1KDM4ESMN1; SMN2HPGDMAPT | |
| SCHEMBL8471730 | 0.77 | MAPT (0.41) | ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1862123 | 0.74 | HTT (0.53) | ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7485658-B2 | N-substituted pyrazolyl-amidyl-benzimidazolyl c-Kit inhibitors | OSI PHARMACEUTICALS, INC. (US) | 2009-02-03 | — | — | US | disclosed |
| EP-1664032-B1 | N-SUBSTITUTED PYRAZOLYL-AMIDYL-BENZIMIDAZOLYL C-KIT INHIBITORS | OSI PHARM INC (US) | 2008-11-05 | — | — | EP | disclosed |
| US-20080221187-A9 | N-substituted pyrazolyl-amidyl-benzimidazolyl c-Kit inhibitors | OSI PHARMACEUTICALS, INC. | 2008-09-11 | — | — | US | disclosed |
| EP-1664032-A1 | N-SUBSTITUTED PYRAZOLYL-AMIDYL-BENZIMIDAZOLYL C-KIT INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| US-20060035951-A1 | N-substituted pyrazolyl-amidyl-benzimidazolyl c-Kit inhibitors | BOLGER JOSHUA | 2006-02-16 | — | — | US | disclosed |
| WO-2005021537-A1 | N-SUBSTITUTED PYRAZOLYL-AMIDYL-BENZIMIDAZOLYL C-KIT INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2005-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221187-A9 | N-substituted pyrazolyl-amidyl-benzimidazolyl c-Kit inhibitors | KIT, TNNI3K, CHUK | ALDH1A1 655/4885KDM4E 742/4885NPC1 2213/4885 |
| US-20060035951-A1 | N-substituted pyrazolyl-amidyl-benzimidazolyl c-Kit inhibitors | KIT, TNNI3K, CHUK | ALDH1A1 655/4885KDM4E 742/4885NPC1 2213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.