Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL1704980 | 1.00 | ALDH1A1 (0.53) | — | |
| Tetrahydrofuran SCHEMBL28650393 | 1.00 | ALDH1A1 (0.53) | — | |
| Acetic Acid SCHEMBL2354574 | 0.97 | ALDH1A1 (0.50) | — | |
| Tetrahydrofuran SCHEMBL7457134 | 0.97 | ALDH1A1 (0.50) | — | |
| Tetrahydrofuran SCHEMBL7645655 | 0.97 | ALDH1A1 (0.50) | — | |
| Tetrahydrofuran SCHEMBL7175965 | 0.97 | ALDH1A1 (0.50) | — | |
| Acetic Acid SCHEMBL4868108 | 0.97 | ALDH1A1 (0.50) | — | |
| Tetrahydrofuran SCHEMBL1056026 | 0.97 | ALDH1A1 (0.50) | — | |
| Tetrahydrofuran SCHEMBL9359499 | 0.97 | ALDH1A1 (0.50) | — | |
| Tetrahydrofuran SCHEMBL7613346 | 0.97 | ALDH1A1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 349 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117071293-A | Preparation method of household antibacterial easy-dyeing ecological regenerated real leather | 浙江禾欣新材料有限公司 | 2023-11-17 | — | — | CN | claimed |
| WO-2023152582-A1 | PROCESS FOR REMOVING IMPURITIES FROM TETRAHYDROFURAN | KOCH TECHNOLOGY SOLUTIONS, LLC (US) | 2023-08-17 | — | — | WO | claimed |
| CN-115703892-A | High-performance degradable epoxy resin-carbon fiber composite material and preparation method thereof | 中南民族大学 | 2023-02-17 | — | — | CN | claimed |
| US-20220135613-A1 | METHOD FOR PREPARING DRUG TOXIN PNU-159682 FOR ANTIBODY DRUG CONJUGATE, AND INTERMEDIATES THEREIN | LEVENA BIOPHARMA CO LTD (CN) | 2022-05-05 | — | — | US | claimed |
| CN-112851623-B | Method for preparing epsilon-caprolactone, 6-hydroxycaproic acid and ester thereof by using tetrahydrofurfuryl acetic acid and ester thereof | 中国科学院兰州化学物理研究所 | 2022-04-08 | — | — | CN | claimed |
| EP-3907223-A1 | METHOD FOR PREPARING DRUG TOXIN PNU-159682 OF ANTIBODY DRUG CONJUGATE, AND INTERMEDIATE THEREIN | Levena Biopharma Co., Ltd. (CN) | 2021-11-10 | — | — | EP | claimed |
| CN-112851623-A | Method for preparing epsilon-caprolactone, 6-hydroxycaproic acid and ester thereof by using tetrahydrofurfuryl acetic acid and ester thereof | 中国科学院兰州化学物理研究所 | 2021-05-28 | — | — | CN | claimed |
| CN-112778241-A | Preparation method of tetrahydrofuran acetic acid and ester compound thereof | 中国科学院兰州化学物理研究所 | 2021-05-11 | — | — | CN | claimed |
| CN-110776501-B | Preparation method of drug toxin PNU-159682 for antibody drug conjugate and intermediate thereof | 联宁（苏州）生物制药有限公司 | 2021-04-02 | — | — | CN | claimed |
| WO-2021031599-A1 | METHOD FOR PREPARING DRUG TOXIN PNU-159682 OF ANTIBODY DRUG CONJUGATE, AND INTERMEDIATE THEREIN | 联宁（苏州）生物制药有限公司 | 2021-02-25 | — | — | WO | claimed |
| US-8299286-B2 | Source reagent compositions and method for forming metal films on a substrate by chemical vapor deposition | ADVANCED TECHNOLOGY MATERIALS, INC. (US) | 2012-10-30 | — | — | US | claimed |
| CN-101235018-B | Modified method for preparing (1,4,5,6-tetrahydro-2-pyrimidyl)thiourea or salts thereof | CHONGQING PHARM RES INST CO | 2011-05-04 | — | — | CN | claimed |
| EP-1636231-B1 | METHODS FOR PREPARING 9-[4-ACETOXY-3-(ACETOXYMETHYL)BUT-1-YL]-2-AMINOPURINE USING A COMPOUND OF 2-AMINO-9-(2-SUBSTITUTED ETHYL)PURINES | KYUNGDONG PHARM CO LTD (KR) | 2010-03-24 | — | — | EP | claimed |
| CN-101235018-A | Modified method for preparing (1,4,5,6-tetrahydro-2-pyrimidyl)thiourea or salts thereof | CHONGQING PHARM RES INST CO (CN) | 2008-08-06 | — | — | CN | claimed |
| CN-1305927-C | Method for processing catalysts for color number hydrogenation of polytetrahydrofuran and/or the esters thereof | BASF AG (DE) | 2007-03-21 | — | — | CN | claimed |
| CN-1271021-C | Process for synthesizing sex pheromone of pine caterpillar | UNIV YUNNAN (CN) | 2006-08-23 | — | — | CN | claimed |
| CN-1557796-A | Process for synthesizing sex pheromone of pine caterpillar | 云南大学 | 2004-12-29 | — | — | CN | claimed |
| US-6429321-B1 | HEATING IN PRESENCE OF ZEOLITE TYPE BETA TO PRODUCE TETRAHYDROFURAN | TCC CHEMICAL CORPORATION (TW) | 2002-08-06 | — | — | US | claimed |
| US-20020022659-A1 | Crystalline and salt forms of an HIV protease inhibitor | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-02-21 | — | — | US | claimed |
| WO-2002006190-A2 | CRYSTALLINE AND SALT FORMS OF AN HIV PROTEASE INHIBITOR | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2002-01-24 | — | — | WO | claimed |