Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 7/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4496455 | 0.93 | LMNA (0.43) | LMNAHPGDTSHRMAPTF10 | |
| SCHEMBL4496459 | 0.93 | LMNA (0.43) | LMNAHPGDTSHRMAPTF10 | |
| SCHEMBL4487765 | 0.87 | LMNA (0.48) | LMNAHPGDTSHRMAPTF10 | |
| SCHEMBL4487769 | 0.87 | LMNA (0.48) | LMNAHPGDTSHRMAPTF10 | |
| SCHEMBL4493709 | 0.86 | LMNA (0.45) | LMNAHPGDTSHRMAPTF10 | |
| SCHEMBL4493714 | 0.86 | LMNA (0.45) | LMNAHPGDTSHRMAPTF10 | |
| SCHEMBL4496450 | 0.84 | F10 (0.44) | LMNAHPGDTSHRMAPTF10 | |
| SCHEMBL4498409 | 0.83 | HPGD (0.56) | LMNAHPGDTSHRMAPTF10 | |
| SCHEMBL4498406 | 0.83 | HPGD (0.56) | LMNAHPGDTSHRMAPTF10 | |
| SCHEMBL4489404 | 0.83 | F10 (0.40) | LMNAHPGDTSHRMAPTF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514468-B2 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2009-04-07 | — | — | US | disclosed |
| US-20060194813-A1 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2006-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194813-A1 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | KDR, FLT1, EGFR | LMNA 1884/4885HPGD 2420/4885TSHR 503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.