Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 0.60 |
| ▸ | GSK3A | P49840 | 2/20 | 0.60 |
| ▸ | CDK2 | P24941 | 1/20 | 0.60 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4493425 | 0.87 | GSK3B (0.68) | GSK3BGSK3AHDAC1HDAC2HDAC8 | |
| SCHEMBL4500115 | 0.85 | GSK3B (0.66) | GSK3BGSK3ACDK2FGFR4HDAC1 | |
| SCHEMBL4498496 | 0.84 | GSK3B (0.67) | GSK3BGSK3ACDK2HDAC1HDAC2 | |
| SCHEMBL4499197 | 0.83 | GSK3B (0.67) | GSK3BGSK3AHDAC1HDAC2HDAC8 | |
| SCHEMBL4490970 | 0.83 | GSK3B (0.65) | GSK3BGSK3AHDAC1HDAC2HDAC8 | |
| SCHEMBL4506071 | 0.82 | GSK3B (0.62) | GSK3BGSK3AHDAC1HDAC2HDAC8 | |
| SCHEMBL4489308 | 0.82 | GSK3B (0.62) | GSK3BGSK3AFGFR4HDAC1HDAC2 | |
| SCHEMBL4494627 | 0.82 | GSK3B (0.60) | GSK3BGSK3ACDK2HDAC1HDAC2 | |
| SCHEMBL4503064 | 0.82 | GSK3B (0.60) | GSK3BGSK3AHDAC1HDAC2HDAC8 | |
| SCHEMBL4483353 | 0.81 | GSK3B (0.70) | GSK3BGSK3ACDK2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |