⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2384 | 0.62 | — | — | |
| SCHEMBL18321327 | 0.59 | — | — | |
| SCHEMBL128941 | 0.59 | — | — | |
| SCHEMBL27480483 | 0.59 | — | — | |
| SCHEMBL6276848 | 0.59 | — | — | |
| SCHEMBL7637912 | 0.59 | — | — | |
| SCHEMBL20420706 | 0.59 | — | — | |
| SCHEMBL22230554 | 0.59 | — | — | |
| SCHEMBL2691891 | 0.59 | — | — | |
| SCHEMBL27496585 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150216861-A1 | CYCLOPROPYL AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2015-08-06 | — | — | US | disclosed |
| US-20150164889-A1 | CYCLOPROPYL AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2015-06-18 | — | — | US | disclosed |
| US-20150164888-A1 | CYCLOPROPYL AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2015-06-18 | — | — | US | disclosed |
| US-9029381-B2 | Cyclopropyl amide derivatives | ASTRAZENECA AB (SE) | 2015-05-12 | — | — | US | disclosed |
| US-8993577-B2 | Cyclopropyl amide derivatives | ASTRAZENECA AB (SE) | 2015-03-31 | — | — | US | disclosed |
| EP-2805937-A1 | Cyclopropyl amide derivatives | AstraZeneca AB (SE) | 2014-11-26 | — | — | EP | disclosed |
| EP-2253615-B1 | Cyclopropyl amide derivatives | ASTRAZENECA AB (SE) | 2014-07-09 | — | — | EP | disclosed |
| EP-2195293-B1 | CYCLOPTOPYL AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2013-10-16 | — | — | EP | disclosed |
| EP-2398780-B1 | CYCLOPROPYL AMIDE DERIVATIVES TARGETING THE HISTAMINE H3 RECEPTOR | ASTRAZENECA AB (SE) | 2013-04-17 | — | — | EP | disclosed |
| US-20120065193-A1 | Cyclopropyl Amide Derivatives '978 | ASTRAZENECA AB (SE) | 2012-03-15 | — | — | US | disclosed |
| US-20100216812-A1 | Cyclopropyl Amide Derivatives | ASTRAZENECA AB (SE) | 2010-08-26 | — | — | US | disclosed |
| EP-2195293-A2 | CYCLOPTOPYL AMIDE DERIVATIVES | AstraZeneca AB (SE) | 2010-06-16 | — | — | EP | disclosed |
| WO-2010062245-A1 | SPIROCYCLOBUTYL PIPERIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2010-06-03 | — | — | WO | disclosed |
| US-20100130477-A1 | Spirocyclobutyl Piperidine Derivatives | ASTRAZENECA AB (SE) | 2010-05-27 | — | — | US | disclosed |
| US-20090076020-A1 | Cyclopropyl Amide Derivatives 978 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | US | disclosed |
| WO-2009024823-A2 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |
| EP-1658298-B1 | PHOSPHORUS-CONTAINING IMIDAZOLINES AND METAL COMPLEXES THEREOF | SOLVIAS AG (CH) | 2008-03-26 | — | — | EP | disclosed |
| US-20070010493-A1 | Phospinite-imidazolines and metal complexes thereof | SOLVIAS AG (CH) | 2007-01-11 | — | — | US | disclosed |
| EP-1658298-A2 | NOVEL ORGANIC COMPOUNDS AND METAL COMPLEXES | Solvias AG (CH) | 2006-05-24 | — | — | EP | disclosed |
| WO-2005021562-A2 | PHOSPINITE-IMIDAZOLINES AND METAL COMPLEXES THEREOF | SOLVIAS AG (CH) | 2005-03-10 | — | — | WO | disclosed |