Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.57 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.56 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4486351 | 0.92 | HDAC6 (0.69) | GSK3BHDAC6FGFR4GSK3AFGFR1 | |
| SCHEMBL4493662 | 0.89 | GSK3B (0.63) | GSK3BHDAC6GSK3AFGFR1FGFR2 | |
| SCHEMBL4503730 | 0.88 | HDAC6 (0.65) | GSK3BHDAC6FGFR4FGFR1FGFR2 | |
| SCHEMBL4496495 | 0.87 | GSK3B (0.64) | GSK3BHDAC6FGFR4TRPA1FGFR1 | |
| SCHEMBL4483422 | 0.86 | HDAC6 (0.62) | GSK3BHDAC6FGFR4GSK3AFGFR1 | |
| SCHEMBL4492586 | 0.84 | GSK3B (0.58) | GSK3BHDAC6FGFR4GSK3ATRPA1 | |
| SCHEMBL4489170 | 0.83 | GSK3B (0.66) | GSK3BHDAC6FGFR4GSK3AFGFR1 | |
| SCHEMBL4495376 | 0.83 | GSK3B (0.64) | GSK3BHDAC6FGFR4TRPA1FGFR1 | |
| SCHEMBL4497843 | 0.83 | GSK3B (0.56) | GSK3BHDAC6GSK3AFGFR1FGFR2 | |
| SCHEMBL4506208 | 0.83 | GSK3B (0.64) | GSK3BHDAC6FGFR4FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |