Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 3/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4490916 | 0.90 | GSK3B (0.59) | GSK3ACDK2HDAC6RAB9AFGFR1 | |
| SCHEMBL4494227 | 0.88 | HDAC6 (0.65) | GSK3ACDK2HDAC6FGFR1FGFR2 | |
| SCHEMBL4482462 | 0.88 | GSK3B (0.63) | GSK3ACDK2HDAC6FGFR1FGFR2 | |
| SCHEMBL4494277 | 0.87 | HDAC6 (0.68) | GSK3ACDK2HDAC6ALDH1A1RAB9A | |
| SCHEMBL4495224 | 0.86 | HDAC6 (0.67) | GSK3ACDK2HDAC6ALDH1A1FGFR1 | |
| SCHEMBL4497998 | 0.85 | HDAC6 (0.65) | GSK3ACDK2HDAC6FGFR1FGFR2 | |
| SCHEMBL4480839 | 0.85 | MAPT (0.60) | GSK3ACDK2HDAC6RAB9AFGFR1 | |
| SCHEMBL4495755 | 0.84 | HDAC6 (0.55) | GSK3ACDK2HDAC6ALDH1A1RAB9A | |
| SCHEMBL4494101 | 0.84 | HDAC6 (0.57) | GSK3ACDK2HDAC6FGFR1FGFR2 | |
| SCHEMBL4488599 | 0.83 | HDAC6 (0.66) | GSK3ACDK2HDAC6ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |