Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 10/20 | 0.41 |
| ▸ | CCND1 | P24385 | 10/20 | 0.41 |
| ▸ | CCND2 | P30279 | 8/20 | 0.41 |
| ▸ | CCND3 | P30281 | 8/20 | 0.41 |
| ▸ | WEE1 | P30291 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL189859 | 0.87 | CCND3 (0.54) | ALDH1A1KDM4EGAAGLAHPGD | |
| SCHEMBL189169 | 0.83 | KDM4E (0.58) | ALDH1A1KDM4EGAAGLAHPGD | |
| SCHEMBL190014 | 0.83 | KDM4E (0.58) | ALDH1A1KDM4EGAAGLAHPGD | |
| SCHEMBL188921 | 0.81 | MAPK1 (0.58) | ALDH1A1KDM4EGAAGLAHPGD | |
| SCHEMBL189897 | 0.81 | KDM4E (0.57) | ALDH1A1KDM4EGAAGLAHPGD | |
| SCHEMBL188366 | 0.78 | MAPK1 (0.52) | ALDH1A1KDM4EGAAGLAHPGD | |
| SCHEMBL4355205 | 0.78 | KDM4E (0.50) | ALDH1A1KDM4EGAAGLAHPGD | |
| SCHEMBL11928210 | 0.76 | KDM4E (0.47) | ALDH1A1KDM4EGAAGLAHPGD | |
| SCHEMBL188696 | 0.76 | CDK4 (0.47) | ALDH1A1KDM4EGAAGLAHPGD | |
| SCHEMBL189479 | 0.74 | ALDH1A1 (0.66) | ALDH1A1KDM4EGAAGLAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056829-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | Exelixis, Inc. (US) | 2009-05-13 | — | — | EP | claimed |
| WO-2008021389-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS, INC. (US) | 2008-02-21 | — | — | WO | claimed |