Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TNKS | O95271 | 3/20 | 0.48 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.48 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.42 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | C1R | P00736 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 2/20 | 0.40 |
| ▸ | GABRD | O14764 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29827309 | 1.00 | KDM4E (0.52) | KDM4EALDH1A1MAPTTNKSTNKS2 | |
| SCHEMBL4510436 | 0.90 | KDM4E (0.52) | KDM4EALDH1A1MAPTTNKSTNKS2 | |
| SCHEMBL4511616 | 0.85 | ALDH1A1 (0.68) | KDM4EALDH1A1MAPTTNKSTNKS2 | |
| SCHEMBL4507834 | 0.85 | ALDH1A1 (0.52) | KDM4EALDH1A1MAPTTNKSTNKS2 | |
| SCHEMBL4502760 | 0.85 | MAPT (0.52) | KDM4EALDH1A1MAPTTNKSTNKS2 | |
| SCHEMBL4497130 | 0.85 | KDM4E (0.52) | KDM4EALDH1A1MAPTTNKSTNKS2 | |
| SCHEMBL4499421 | 0.84 | TNKS (0.51) | KDM4EALDH1A1MAPTTNKSTNKS2 | |
| SCHEMBL4501935 | 0.84 | KDM4E (0.53) | KDM4EALDH1A1MAPTTNKSTNKS2 | |
| SCHEMBL4495351 | 0.82 | KMT2A (0.52) | KDM4EALDH1A1MAPTTNKSTNKS2 | |
| SCHEMBL4502490 | 0.81 | KDM4E (0.48) | KDM4EALDH1A1MAPTTNKSPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318479-A1 | SUBSTITUTED RING FUSED AZINES AND THEIR USE IN CANCER THERAPY | AUCKLAND UNISERVICES LIMITED | 2009-12-24 | — | — | US | claimed |
| CN-113072543-B | 2-aromatic heterocyclic quinazoline ketone compound and preparation method and application thereof | 南方医科大学 | 2022-07-22 | — | — | CN | disclosed |
| CN-113072543-A | 2-aromatic heterocyclic quinazoline ketone compound and preparation method and application thereof | 南方医科大学 | 2021-07-06 | — | — | CN | disclosed |
| US-20090318479-A1 | SUBSTITUTED RING FUSED AZINES AND THEIR USE IN CANCER THERAPY | AUCKLAND UNISERVICES LIMITED | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318479-A1 | SUBSTITUTED RING FUSED AZINES AND THEIR USE IN CANCER THERAPY | TP53, AZI2, MCL1 | KDM4E 221/4885ALDH1A1 217/4885MAPT 4852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.