Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 19/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | BCR | P11274 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4480331 | 0.93 | GSK3B (0.61) | GSK3BCYP1A2ABL1BCR | |
| SCHEMBL4480187 | 0.90 | GSK3B (0.59) | GSK3BCYP1A2 | |
| SCHEMBL4499724 | 0.90 | GSK3B (0.62) | GSK3BCYP1A2ABL1BCR | |
| SCHEMBL4558529 | 0.90 | GSK3B (0.65) | GSK3BCYP1A2ABL1BCR | |
| SCHEMBL4485356 | 0.89 | GSK3B (0.57) | GSK3BCYP1A2 | |
| SCHEMBL4492112 | 0.89 | GSK3B (0.61) | GSK3BCYP1A2ABL1BCR | |
| SCHEMBL4559844 | 0.88 | HDAC6 (0.62) | GSK3B | |
| SCHEMBL4492939 | 0.88 | GSK3B (0.60) | GSK3BABL1BCR | |
| SCHEMBL12886269 | 0.86 | GSK3B (0.58) | GSK3BCYP1A2ABL1BCR | |
| SCHEMBL4486390 | 0.85 | GSK3B (0.62) | GSK3BCYP1A2ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |