Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 17/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4502574 | 0.94 | GSK3B (0.57) | GSK3BCYP1A2HDAC6FGFR1FGFR2 | |
| SCHEMBL4488734 | 0.90 | GSK3B (0.53) | GSK3BCYP1A2HDAC6FGFR1FGFR2 | |
| SCHEMBL4494624 | 0.90 | GSK3B (0.53) | GSK3BCYP1A2HDAC6FGFR1FGFR2 | |
| SCHEMBL4497067 | 0.90 | GSK3B (0.64) | GSK3BCYP1A2 | |
| SCHEMBL4498152 | 0.89 | GSK3B (0.52) | GSK3BCYP1A2HDAC6FGFR1FGFR2 | |
| SCHEMBL4505096 | 0.89 | GSK3B (0.51) | GSK3BCYP1A2HDAC6FGFR1FGFR2 | |
| SCHEMBL12886381 | 0.89 | GSK3B (0.52) | GSK3BCYP1A2HDAC6FGFR1FGFR2 | |
| SCHEMBL12886413 | 0.88 | GSK3B (0.62) | GSK3BCYP1A2HDAC6FGFR1FGFR2 | |
| SCHEMBL4480967 | 0.88 | GSK3B (0.64) | GSK3BCYP1A2HDAC6FGFR1FGFR2 | |
| SCHEMBL4494405 | 0.88 | GSK3B (0.55) | GSK3BCYP1A2HDAC6FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |