Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.51 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.50 |
| ▸ | LCK | P06239 | 4/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | TTK | P33981 | 1/20 | 0.47 |
| ▸ | STK10 | O94804 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | TIE1 | P35590 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | TEK | Q02763 | 1/20 | 0.46 |
| ▸ | MERTK | Q12866 | 1/20 | 0.46 |
| ▸ | SIK1 | P57059 | 2/20 | 0.46 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4497902 | 0.96 | AXL (0.51) | AXLTNK2LCKKDRSRC | |
| SCHEMBL4480180 | 0.93 | TNK2 (0.48) | AXLTNK2LCKKDRSRC | |
| SCHEMBL4493587 | 0.92 | LCK (0.50) | AXLTNK2LCKKDRSRC | |
| SCHEMBL4496749 | 0.92 | TNK2 (0.50) | AXLTNK2LCKKDRSRC | |
| SCHEMBL4491249 | 0.91 | ITK (0.47) | AXLTNK2LCKTTKBTK | |
| SCHEMBL4498571 | 0.91 | TNK2 (0.50) | AXLTNK2LCKKDRSRC | |
| SCHEMBL5687088 | 0.91 | TNK2 (0.50) | AXLTNK2LCKKDRSRC | |
| SCHEMBL4499613 | 0.91 | TNK2 (0.47) | AXLTNK2LCKKDRSRC | |
| SCHEMBL4498813 | 0.91 | SIK1 (0.44) | AXLTNK2LCKKDRTTK | |
| SCHEMBL4507099 | 0.90 | TNK2 (0.54) | TNK2LCKKDRSRCMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050209221-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. | 2005-09-22 | — | — | US | claimed |
| US-7504396-B2 | Substituted heterocyclic compounds and methods of use | AMGEN INC. (US) | 2009-03-17 | — | — | US | disclosed |
| US-20050209221-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. | 2005-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209221-A1 | Substituted heterocyclic compounds and methods of use | ICOS, CD4, HLA-DRB1 | AXL 2557/4885TNK2 1854/4885LCK 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.