Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.47 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22925624 | 0.81 | NOTUM (0.62) | NOTUMPDCD1CD274 | |
| SCHEMBL181974 | 0.75 | NOTUM (0.67) | NOTUMPDCD1CD274KDM4EALDH1A1 | |
| SCHEMBL28698600 | 0.73 | NOTUM (0.47) | NOTUMPDCD1CD274PGRXDH | |
| SCHEMBL12209197 | 0.72 | NOTUM (0.49) | NOTUMPDCD1CD274IDO1BRD4 | |
| SCHEMBL22348268 | 0.72 | SMN1; SMN2 (0.49) | NOTUMPGRIDO1KDM4EALDH1A1 | |
| SCHEMBL29678302 | 0.70 | TSHR (0.58) | NOTUMPGRMAOBIDO1ALDH1A1 | |
| SCHEMBL1263144 | 0.70 | TSHR (0.58) | NOTUMPGRMAOBIDO1ALDH1A1 | |
| SCHEMBL10448419 | 0.70 | NOTUM (0.47) | NOTUMPDCD1CD274PGRXDH | |
| SCHEMBL11625391 | 0.69 | SMN1; SMN2 (0.59) | NOTUMPDCD1CD274XDHPARP10 | |
| SCHEMBL12209194 | 0.69 | F10 (0.44) | NOTUMIDO1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065063-A1 | 3-Aryl-4-(2,6-dimethylbenzylidene)isoxazol-5(4H)-ones as Fungicides | BAYER CROPSCIENCE AG (DE) | 2012-03-15 | — | — | US | disclosed |
| WO-2011161034-A1 | 3-ARYL-4-(2,6-DIMETHYLBENZYLIDENE)-ISOXAZOL-5(4H)-ONES AS FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2011-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065063-A1 | 3-Aryl-4-(2,6-dimethylbenzylidene)isoxazol-5(4H)-ones as Fungicides | CYP4X1, CYP4Z1, HAAO | NOTUM 1120/4885PDCD1 1209/4885CD274 1697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.