Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.57 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 5/20 | 0.55 |
| ▸ | GSK3A | P49840 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4489306 | 0.91 | HDAC6 (0.57) | HDAC6TRPA1FGFR1FGFR2FGFR3 | |
| SCHEMBL4502187 | 0.89 | GSK3B (0.69) | HDAC6FGFR1FGFR2FGFR3GSK3B | |
| SCHEMBL4490307 | 0.87 | HDAC6 (0.57) | HDAC6FGFR1FGFR2FGFR3GSK3B | |
| SCHEMBL4488340 | 0.87 | HDAC6 (0.66) | HDAC6FGFR1FGFR2FGFR3GSK3B | |
| SCHEMBL4489919 | 0.87 | HDAC6 (0.54) | HDAC6FGFR1FGFR2FGFR3GSK3B | |
| SCHEMBL4488584 | 0.86 | HDAC6 (0.59) | HDAC6FGFR1FGFR2FGFR3GSK3B | |
| SCHEMBL4500708 | 0.86 | GSK3B (0.67) | HDAC6FGFR1FGFR2FGFR3GSK3B | |
| SCHEMBL4486523 | 0.85 | FGFR2 (0.55) | HDAC6FGFR1FGFR2FGFR3GSK3B | |
| SCHEMBL4496041 | 0.85 | FGFR1 (0.53) | HDAC6FGFR1FGFR2FGFR3GSK3B | |
| SCHEMBL4491482 | 0.85 | GSK3B (0.61) | HDAC6FGFR1FGFR2FGFR3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |