⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL46494 | 0.80 | — | — | |
| SCHEMBL19173 | 0.80 | — | — | |
| Water SCHEMBL29860131 | 0.78 | DYRK1A (0.41) | — | |
| SCHEMBL31338725 | 0.78 | PDE10A (0.45) | — | |
| Hydrochloric Acid SCHEMBL30128120 | 0.78 | DYRK1A (0.41) | — | |
| SCHEMBL3962541 | 0.78 | DYRK1A (0.41) | — | |
| SCHEMBL31674379 | 0.78 | PDE10A (0.45) | — | |
| Hydrochloric Acid SCHEMBL6894527 | 0.78 | PDE10A (0.45) | — | |
| SCHEMBL31237159 | 0.78 | DYRK1A (0.41) | — | |
| Iodide SCHEMBL9950363 | 0.78 | DYRK1A (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 172 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115710-A1 | PROCESS FOR PREPARING REGIOSPECIFIC SUBSTITUTED PYRAZINE ISOMERS | ABBOTT LABORATORIES (US) | 2001-07-18 | — | — | EP | claimed |
| WO-2000010983-A1 | PROCESS FOR PREPARING REGIOSPECIFIC SUBSTITUTED PYRAZINE ISOMERS | ABBOTT LABORATORIES (US) | 2000-03-02 | — | — | WO | claimed |
| EP-4219465-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2023-08-02 | — | — | EP | disclosed |
| US-20230144197-A1 | 4-[[(7-AMINOPYRAZOLO[1,5-A]PYRIMIDIN-5-YL)AMINO]METHYL]PIPERIDIN-3-OL COMPOUNDS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2023-05-11 | — | — | US | disclosed |
| US-20230144197-A1 | 4-[[(7-AMINOPYRAZOLO[1,5-A]PYRIMIDIN-5-YL)AMINO]METHYL]PIPERIDIN-3-OL COMPOUNDS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2023-05-11 | — | — | US | disclosed |
| EP-3498701-B1 | PRMT5 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2023-02-22 | — | — | EP | disclosed |
| US-11197857-B2 | Combination therapy | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-12-14 | — | — | US | disclosed |
| US-11185531-B2 | Arginine methyltransferase inhibitors and uses thereof | Epizyme, Inc. (US) | 2021-11-30 | — | — | US | disclosed |
| WO-2021122745-A1 | 4-[[(7-AMINOPYRAZOLO[1,5-A]PYRIMIDIN-5-YL)AMINO]METHYL]PIPERIDIN-3-OL COMPOUNDS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2021-06-24 | — | — | WO | disclosed |
| US-20210106580-A1 | COMBINATION THERAPY | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-04-15 | — | — | US | disclosed |
| US-20210078951-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. | 2021-03-18 | — | — | US | disclosed |
| US-20090286796-A1 | Compounds exhibiting type X sPLA2 inhibiting effect | OGAWA TOMOYUKI | 2009-11-19 | — | — | US | disclosed |
| US-20090134780-A1 | Electron transport material and organic electroluminescent device using the same | SK MATERIALS JNC CO., LTD. (KR) | 2009-05-28 | — | — | US | disclosed |
| US-20090134780-A1 | Electron transport material and organic electroluminescent device using the same | SK MATERIALS JNC CO., LTD. (KR) | 2009-05-28 | — | — | US | disclosed |
| US-20060116379-A1 | Compounds exhibiting type X sPLA2 inhibiting effect | OGAWA TOMOYUKI | 2006-06-01 | — | — | US | disclosed |
| US-7026318-B2 | Compounds exhibiting X-type sPLA2 inhibiting effect | SHIONOGI & CO., LTD. (JP) | 2006-04-11 | — | — | US | disclosed |
| US-20030181454-A1 | Compounds exhibiting x-type spla2 inibiting effect | SHIONOGI & CO., LTD. (JP) | 2003-09-25 | — | — | US | disclosed |
| EP-1115710-A1 | PROCESS FOR PREPARING REGIOSPECIFIC SUBSTITUTED PYRAZINE ISOMERS | ABBOTT LABORATORIES (US) | 2001-07-18 | — | — | EP | disclosed |
| CN-1304410-A | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them | ASTRA ZENECA LTD (SE) | 2001-07-18 | — | — | CN | disclosed |
| WO-2000010983-A1 | PROCESS FOR PREPARING REGIOSPECIFIC SUBSTITUTED PYRAZINE ISOMERS | ABBOTT LABORATORIES (US) | 2000-03-02 | — | — | WO | disclosed |