Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.48 |
| ▸ | NQO2 | P16083 | 1/20 | 0.48 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.48 |
| ▸ | ACTR2 | P61160 | 1/20 | 0.48 |
| ▸ | CCR1 | P32246 | 12/20 | 0.42 |
| ▸ | FPR3 | P25089 | 1/20 | 0.40 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13936133 | 1.00 | MAPK14 (0.48) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL4499666 | 1.00 | MAPK14 (0.48) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL4495958 | 0.91 | MAPK14 (0.51) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL4495960 | 0.91 | MAPK14 (0.51) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL4495613 | 0.90 | MAPK14 (0.60) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL4488849 | 0.90 | MAPK14 (0.60) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL14539725 | 0.86 | MAPK14 (0.39) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL4512801 | 0.84 | MAPK14 (0.53) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL4512803 | 0.84 | MAPK14 (0.53) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL5619016 | 0.83 | MAPK14 (0.56) | MAPK14MAPK11MAPK13MAPK12NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7488744-B2 | Indole-type derivatives as inhibitors of p38 kinase | SCIOS, INC. (US) | 2009-02-10 | — | — | US | disclosed |
| US-20070232617-A1 | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF P38 KINASE | SCIOS, INC. (US) | 2007-10-04 | — | — | US | disclosed |
| US-7220763-B2 | Indole-type derivatives as inhibitors of p38 kinase | SCIOS, INC. (US) | 2007-05-22 | — | — | US | disclosed |
| US-20040142940-A1 | Indole-type derivatives as inhibitors of p38 kinase | SCIOS, INC. | 2004-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142940-A1 | Indole-type derivatives as inhibitors of p38 kinase | MAPK1, MAPKAPK2, MAPK4 | MAPK14 28/4885MAPK11 48/4885MAPK13 38/4885 |
| US-20070232617-A1 | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF P38 KINASE | MAPK1, MAPKAPK2, MAPKAPK5 | MAPK14 38/4885MAPK11 52/4885MAPK13 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.