SCHEMBL14539725 — predicted protein targets

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	MAPK14	Q16539	5/20	0.39

▸	MAPK11	Q15759	2/20	0.39

▸	MAPK13	O15264	1/20	0.39

▸	MAPK12	P53778	1/20	0.39

▸	NQO2	P16083	1/20	0.39

▸	MAPKAPK2	P49137	1/20	0.39

▸	ACTR2	P61160	1/20	0.39

▸	MLNR	O43193	4/20	0.33

▸	CYP3A4	P08684	3/20	0.33

▸	GRM2	Q14416	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL14539716	0.89	MAPK14 (0.38)	MAPK14MAPK11MAPK13MAPK12NQO2
SCHEMBL4499661	0.86	MAPK14 (0.48)	MAPK14MAPK11MAPK13MAPK12NQO2
SCHEMBL4499666	0.86	MAPK14 (0.48)	MAPK14MAPK11MAPK13MAPK12NQO2
SCHEMBL13936133	0.86	MAPK14 (0.48)	MAPK14MAPK11MAPK13MAPK12NQO2
SCHEMBL4495613	0.82	MAPK14 (0.60)	MAPK14MAPK11MAPK13MAPK12NQO2
SCHEMBL4488849	0.82	MAPK14 (0.60)	MAPK14MAPK11MAPK13MAPK12NQO2
SCHEMBL14539717	0.81	MAPK14 (0.45)	MAPK14MAPK11MAPK13MAPK12NQO2
SCHEMBL14539786	0.79	MAPK14 (0.45)	MAPK14MAPK11MAPK13MAPK12NQO2
SCHEMBL14539721	0.79	MAPK14 (0.49)	MAPK14MAPK11MAPK13MAPK12NQO2
SCHEMBL14539804	0.79	MAPK14 (0.49)	MAPK14MAPK11MAPK13MAPK12NQO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-7220763-B2	Indole-type derivatives as inhibitors of p38 kinase	SCIOS, INC. (US)	2007-05-22	—	—	US	disclosed