Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | LIPE | Q05469 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | DRD1 | P21728 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL85721 | 0.83 | CYP2D6 (0.55) | CYP2D6CYP2C19LIPECHRM2ADRA2A | |
| SCHEMBL27466737 | 0.82 | CYP2D6 (0.46) | CYP2D6CYP2C19LIPECHRM2ADRA2A | |
| SCHEMBL3989090 | 0.82 | CYP2D6 (0.44) | CYP2D6CYP2C19LIPECHRM2ADRA2A | |
| SCHEMBL11701431 | 0.82 | CYP2D6 (0.44) | CYP2D6CYP2C19LIPECHRM2ADRA2A | |
| SCHEMBL7553092 | 0.79 | CYP2D6 (0.47) | CYP2D6CYP2C19LIPECHRM2ADRA2A | |
| SCHEMBL4953723 | 0.79 | POLB (0.44) | CYP2D6CYP2C19LIPECHRM2ADRA2A | |
| SCHEMBL4953717 | 0.79 | POLB (0.44) | CYP2D6CYP2C19LIPECHRM2ADRA2A | |
| SCHEMBL21884184 | 0.78 | CYP2D6 (0.42) | CYP2D6CYP2C19LIPECHRM2ADRA2A | |
| SCHEMBL8803105 | 0.78 | POLB (0.43) | CYP2D6CYP2C19LIPELMNATSHR | |
| SCHEMBL8716295 | 0.76 | TSHR (0.32) | KDM4ETSHRHSD17B10ALDH1A1KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598387-B2 | Synthesis of antidiabetic rosiglitazone derivatives | CIPLA LIMITED (IN) | 2009-10-06 | — | — | US | disclosed |
| EP-1756099-B1 | SYNTHESIS OF ANTIDIABETIC ROSIGLITAZONE DERIVATIVES | CIPLA LTD (IN) | 2008-11-12 | — | — | EP | disclosed |
| US-20070191611-A1 | Synthesis of antidiabetic rosigltazone derivatives | CIPLA LIMITED (IN) | 2007-08-16 | — | — | US | disclosed |
| WO-2002051823-A1 | PROCESS FOR THE PREPARATION OF ROSIGLITAZONE MALEATE | TORRENT PHARMACEUTICALS LTD (IN) | 2002-07-04 | — | — | WO | disclosed |
| US-5932601-A | USEFUL FOR LOWERING BLOOD SUGAR AND LIPID IN BLOOD | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191611-A1 | Synthesis of antidiabetic rosigltazone derivatives | PPARD, PPARG, GLP1R | CYP2D6 309/4885CYP2C19 217/4885LIPE 915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.