Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7070214 | 0.64 | CHRM2 (0.42) | TSHRTDP1AKR1B1NPC1MAPK13 | |
| SCHEMBL9194271 | 0.64 | NPC1 (0.44) | TSHRTDP1AKR1B1NPC1MAPK13 | |
| SCHEMBL2061748 | 0.61 | CHRM2 (0.49) | TSHRTDP1AKR1B1NPC1MAPK13 | |
| SCHEMBL29858318 | 0.61 | CHRM2 (0.49) | TSHRTDP1AKR1B1NPC1MAPK13 | |
| SCHEMBL24481803 | 0.60 | HTR2A (0.50) | TSHRTDP1AKR1B1HTR2A | |
| SCHEMBL14037991 | 0.60 | KDM1A (0.47) | TSHRTDP1HTR2A | |
| SCHEMBL19565413 | 0.60 | KDM1A (0.47) | HTR2A | |
| SCHEMBL7884175 | 0.59 | HTR2A (0.67) | TSHRTDP1AKR1B1NPC1MAPK13 | |
| SCHEMBL10599632 | 0.59 | TSHR (1.00) | TSHRTDP1AKR1B1 | |
| SCHEMBL17605022 | 0.59 | TSHR (1.00) | TSHRTDP1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582667-B2 | Dihydrospiro[dibenzo[a,d][7]annulene-5,4′-imidazol] compounds for the inhibition of beta-secretase | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| US-7582667-B2 | Dihydrospiro[dibenzo[a,d][7]annulene-5,4′-imidazol] compounds for the inhibition of beta-secretase | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| WO-2007100536-A1 | DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE | WYETH (US) | 2007-09-07 | — | — | WO | disclosed |
| WO-2007100536-A1 | DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE | WYETH (US) | 2007-09-07 | — | — | WO | disclosed |
| US-20070203116-A1 | Dihydrospiro[dibenzo[a,d][7]annulene-5,4'-imidazol] compounds for the inhibition of beta-secretase | WYETH (US) | 2007-08-30 | — | — | US | disclosed |
| US-20070203116-A1 | Dihydrospiro[dibenzo[a,d][7]annulene-5,4'-imidazol] compounds for the inhibition of beta-secretase | WYETH (US) | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203116-A1 | Dihydrospiro[dibenzo[a,d][7]annulene-5,4'-imidazol] compounds for the inhibition of beta-secretase | BACE1, BACE2, APP | TSHR 4792/4885TDP1 243/4885AKR1B1 763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.