Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4487834 | 0.93 | CYP1A2 (0.54) | HDAC1HDAC2HDAC8HDAC6FGFR4 | |
| SCHEMBL4491832 | 0.86 | HDAC1 (0.63) | HDAC1HDAC2HDAC8HDAC6FGFR1 | |
| SCHEMBL4496861 | 0.86 | HDAC1 (0.63) | HDAC1HDAC2HDAC8HDAC6FGFR1 | |
| SCHEMBL4502572 | 0.86 | HDAC1 (0.65) | HDAC1HDAC2HDAC8HDAC6FGFR1 | |
| SCHEMBL4494927 | 0.85 | HDAC6 (0.69) | HDAC1HDAC2HDAC8HDAC6FGFR1 | |
| SCHEMBL4506085 | 0.85 | HDAC1 (0.64) | HDAC1HDAC2HDAC8HDAC6FGFR1 | |
| SCHEMBL4490316 | 0.84 | HDAC1 (0.63) | HDAC1HDAC2HDAC8HDAC6FGFR1 | |
| SCHEMBL4489163 | 0.83 | HDAC1 (0.62) | HDAC1HDAC2HDAC8HDAC6FGFR1 | |
| SCHEMBL12886130 | 0.83 | HDAC6 (0.57) | HDAC1HDAC2HDAC8HDAC6FGFR1 | |
| SCHEMBL4476288 | 0.82 | HDAC1 (0.66) | HDAC1HDAC2HDAC8HDAC6FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |