Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.33 |
| ▸ | CDK2 | P24941 | 10/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.32 |
| ▸ | CDK9 | P50750 | 5/20 | 0.32 |
| ▸ | CDK1 | P06493 | 3/20 | 0.32 |
| ▸ | CDK4 | P11802 | 3/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.32 |
| ▸ | CCND1 | P24385 | 3/20 | 0.32 |
| ▸ | CDK7 | P50613 | 3/20 | 0.32 |
| ▸ | CCNH | P51946 | 3/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.32 |
| ▸ | CDK3 | Q00526 | 3/20 | 0.32 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.32 |
| ▸ | WDR5 | P61964 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 3/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29868 | 0.85 | — | — | |
| SCHEMBL2146905 | 0.85 | — | — | |
| SCHEMBL2147725 | 0.81 | EIF2AK4 (0.32) | — | |
| SCHEMBL17787559 | 0.81 | CHEK1 (0.36) | CDK2CCNA2CCNA1WDR5JAK1 | |
| SCHEMBL2147516 | 0.76 | KCNK3 (0.31) | — | |
| SCHEMBL14299172 | 0.76 | CHEK1 (0.37) | CDK2CCNT1CDK9CCNA2CCNA1 | |
| SCHEMBL2147142 | 0.76 | — | — | |
| SCHEMBL2724822 | 0.75 | HTR1D (0.31) | — | |
| SCHEMBL2147714 | 0.73 | WDR5 (0.30) | WDR5 | |
| SCHEMBL2147721 | 0.73 | WDR5 (0.30) | WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027234-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |
| WO-2012027240-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |