Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 7/20 | 0.71 |
| ▸ | DRD2 | P14416 | 5/20 | 0.71 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.71 |
| ▸ | DRD4 | P21917 | 4/20 | 0.71 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.71 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.71 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.71 |
| ▸ | HTR1A | P08908 | 2/20 | 0.71 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.71 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.71 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.71 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.71 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.71 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.71 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 6/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4490238 | 0.94 | DRD2 (0.69) | HRH1DRD2CHRM1DRD4CHRM3 | |
| SCHEMBL4502742 | 0.90 | DRD2 (0.68) | HRH1DRD2CHRM1DRD4CHRM3 | |
| SCHEMBL27543458 | 0.86 | HRH1 (0.53) | HRH1DRD2CHRM1DRD4CHRM3 | |
| SCHEMBL4500671 | 0.85 | DRD2 (0.67) | HRH1DRD2CHRM1DRD4CHRM3 | |
| SCHEMBL4501010 | 0.83 | DRD2 (0.75) | HRH1DRD2CHRM1DRD4CHRM3 | |
| SCHEMBL31060842 | 0.83 | DRD2 (1.00) | HRH1DRD2CHRM1DRD4CHRM3 | |
| SCHEMBL4504348 | 0.83 | DRD2 (1.00) | HRH1DRD2CHRM1DRD4CHRM3 | |
| Hydrochloric Acid SCHEMBL4171949 | 0.82 | CHRM1 (1.00) | HRH1DRD2CHRM1DRD4CHRM3 | |
| SCHEMBL4500204 | 0.81 | DRD2 (0.72) | HRH1DRD2CHRM1DRD4CHRM3 | |
| SCHEMBL4498435 | 0.81 | CHRM1 (0.72) | HRH1DRD2CHRM1DRD4CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7485651-B2 | Compounds with activity on muscarinic receptors | ACADIA PHARMACEUTICALS, INC. (US) | 2009-02-03 | — | — | US | disclosed |
| US-20080108618-A1 | COMPOUNDS WITH ACTIVITY ON MUSCARINIC RECEPTORS | BRANN MARK | 2008-05-08 | — | — | US | disclosed |
| US-20030144285-A1 | Compounds with activity on muscarinic receptors | BRANN MARK (US) | 2003-07-31 | — | — | US | disclosed |
| US-6528529-B1 | 4-Methoxy-1-(4-(2-methylphenyl)-4-oxo-1-butyl)piperidine | ACADIA PHARMACEUTICALS INC. | 2003-03-04 | — | — | US | disclosed |
| WO-2001005763-A2 | COMPOUNDS WITH ACTIVITY ON MUSCARINIC RECEPTORS | ACADIA PHARMACEUTICALS, INC. (US) | 2001-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108618-A1 | COMPOUNDS WITH ACTIVITY ON MUSCARINIC RECEPTORS | CHRM3, CHRM2, CHRM1 | HRH1 71/4885DRD2 470/4885CHRM1 3/4885 |
| US-20030144285-A1 | Compounds with activity on muscarinic receptors | CHRM3, CHRM2, CHRM1 | HRH1 71/4885DRD2 470/4885CHRM1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.