Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL451038 | 0.91 | BACE1 (0.67) | BACE1CTSD | |
| Trifluoroacetic Acid SCHEMBL448556 | 0.84 | BACE1 (0.59) | BACE1CTSD | |
| Trifluoroacetic Acid SCHEMBL450524 | 0.84 | CTSD (0.84) | BACE1CTSD | |
| SCHEMBL431152 | 0.73 | BACE1 (1.00) | BACE1CTSD | |
| SCHEMBL430635 | 0.73 | BACE1 (0.67) | BACE1CTSD | |
| SCHEMBL446207 | 0.73 | BACE1 (0.67) | BACE1CTSD | |
| SCHEMBL449471 | 0.72 | BACE1 (0.65) | BACE1CTSD | |
| SCHEMBL1981997 | 0.71 | BACE1 (1.00) | BACE1CTSD | |
| SCHEMBL445967 | 0.71 | BACE1 (0.59) | BACE1CTSD | |
| SCHEMBL445968 | 0.71 | BACE1 (0.59) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065195-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065195-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | APP, BACE1, PSEN1 | BACE1 2/4885CTSD 427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.