Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 14/20 | 0.60 |
| ▸ | KDR | P35968 | 13/20 | 0.60 |
| ▸ | CSF1R | P07333 | 11/20 | 0.60 |
| ▸ | FLT3 | P36888 | 6/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | MET | P08581 | 3/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4505823 | 0.84 | PDGFRB (0.78) | PDGFRBKDRCSF1RFLT3KCNH2 | |
| SCHEMBL4498690 | 0.82 | KDR (0.53) | PDGFRBKDRCSF1RFLT3KCNH2 | |
| SCHEMBL5009418 | 0.81 | KDR (0.56) | PDGFRBKDRCSF1RFLT3KCNH2 | |
| SCHEMBL4501673 | 0.81 | PDGFRB (0.56) | PDGFRBKDRCSF1RFLT3KCNH2 | |
| SCHEMBL4514154 | 0.81 | KDR (0.52) | PDGFRBKDRCSF1RFLT3KCNH2 | |
| SCHEMBL4503422 | 0.80 | PDGFRB (0.80) | PDGFRBKDRCSF1RFLT3KCNH2 | |
| SCHEMBL4981120 | 0.80 | PDGFRB (0.65) | PDGFRBKDRCSF1RFLT3KCNH2 | |
| SCHEMBL4514447 | 0.80 | PDGFRB (0.53) | PDGFRBKDRCSF1RFLT3KCNH2 | |
| SCHEMBL2173631 | 0.79 | KDR (0.69) | PDGFRBKDRCSF1RFLT3MET | |
| SCHEMBL4499095 | 0.79 | PDGFRB (0.54) | PDGFRBKDRCSF1RFLT3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090076075-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | US | claimed |
| US-20090076075-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076075-A1 | QUINOLINE DERIVATIVES | RECQL, NQO2, NRAS | PDGFRB 1820/4885KDR 2118/4885CSF1R 588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.