Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.69 |
| ▸ | FLT3 | P36888 | 8/20 | 0.69 |
| ▸ | CSF1R | P07333 | 5/20 | 0.69 |
| ▸ | MET | P08581 | 8/20 | 0.65 |
| ▸ | FLT4 | P35916 | 2/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.57 |
| ▸ | KIT | P10721 | 3/20 | 0.57 |
| ▸ | RET | P07949 | 2/20 | 0.56 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.52 |
| ▸ | STK10 | O94804 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | LYN | P07948 | 1/20 | 0.52 |
| ▸ | BCR | P11274 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2174528 | 0.92 | FLT3 (0.64) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL2175384 | 0.92 | FLT3 (0.64) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL2172864 | 0.92 | KDR (0.63) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL4981120 | 0.88 | PDGFRB (0.65) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL2173815 | 0.86 | MET (0.68) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL2172536 | 0.83 | KDR (0.81) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL5591960 | 0.83 | PDGFRB (0.56) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL2173585 | 0.82 | MET (0.70) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL2177733 | 0.82 | KDR (0.63) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL2176626 | 0.82 | PDGFRB (0.81) | KDRPDGFRBFLT3CSF1RMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973164-B2 | Quinoline derivatives | ASTRAZENECA AB (SE) | 2011-07-05 | — | — | US | claimed |