Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 11/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.60 |
| ▸ | FPR2 | P25090 | 2/20 | 0.57 |
| ▸ | MMP12 | P39900 | 3/20 | 0.52 |
| ▸ | MMP13 | P45452 | 2/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL27744406 | 1.00 | ROCK2 (0.60) | ROCK2ROCK1FPR2MMP12MMP13 | |
| Trifluoroacetic Acid SCHEMBL4523856 | 1.00 | ROCK2 (0.60) | ROCK2ROCK1FPR2MMP12MMP13 | |
| SCHEMBL4533295 | 0.93 | ROCK2 (0.68) | ROCK2ROCK1FPR2MMP12MMP13 | |
| SCHEMBL4529785 | 0.93 | ROCK2 (0.68) | ROCK2ROCK1FPR2MMP12MMP13 | |
| SCHEMBL4513691 | 0.84 | ROCK2 (0.56) | ROCK2ROCK1FPR2MMP12MMP13 | |
| SCHEMBL27744401 | 0.84 | ROCK2 (0.56) | ROCK2ROCK1FPR2MMP12MMP13 | |
| SCHEMBL4523861 | 0.84 | ROCK2 (0.56) | ROCK2ROCK1FPR2MMP12MMP13 | |
| SCHEMBL4525223 | 0.83 | ROCK1 (0.65) | ROCK2ROCK1FPR2MMP12MMP13 | |
| SCHEMBL27744457 | 0.83 | ROCK1 (0.65) | ROCK2ROCK1FPR2MMP12MMP13 | |
| SCHEMBL4515485 | 0.83 | ROCK1 (0.65) | ROCK2ROCK1FPR2MMP12MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211919-B2 | Amide derivatives as rock inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-07-03 | — | — | US | disclosed |
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ROCK1, ROCK2, RHOA | ROCK2 2/4885ROCK1 1/4885FPR2 3158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.