Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | AGXT | P21549 | 1/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL12987906 | 0.98 | RAB9A (0.44) | RAB9ANPC1ALDH1A1LMNATHRB | |
| SCHEMBL24620886 | 0.86 | NPC1 (0.46) | NPC1LMNAFLT3LOXL2TSHR | |
| SCHEMBL9025596 | 0.83 | KMT2A (0.43) | RAB9ANPC1LMNAFLT3LOXL2 | |
| SCHEMBL9025978 | 0.82 | CYP19A1 (0.43) | RAB9ANPC1ALDH1A1LMNAFLT3 | |
| SCHEMBL29772198 | 0.82 | CFTR (0.42) | ALDH1A1L3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL22105645 | 0.82 | CFTR (0.42) | ALDH1A1L3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL24621095 | 0.81 | CYP19A1 (0.42) | RAB9ANPC1ALDH1A1FLT3LOXL2 | |
| SCHEMBL28559346 | 0.80 | RAB9A (0.44) | RAB9ANPC1ALDH1A1LMNATHRB | |
| SCHEMBL8867049 | 0.79 | NPC1 (0.44) | RAB9ANPC1ALDH1A1LMNATHRB | |
| SCHEMBL10362278 | 0.77 | CYP2D6 (0.46) | RAB9ANPC1ALDH1A1LMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054445-A1 | Amide Substituted Quinolines | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | US | claimed |
| EP-1981882-A1 | AMIDE SUBSTITUTED QUINOLINES | AstraZeneca AB (SE) | 2008-10-22 | — | — | EP | claimed |
| WO-2007086799-A1 | AMIDE SUBSTITUTED QUINOLINES | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | claimed |
| US-20090054445-A1 | Amide Substituted Quinolines | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | US | disclosed |
| EP-1981882-A1 | AMIDE SUBSTITUTED QUINOLINES | AstraZeneca AB (SE) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007086799-A1 | AMIDE SUBSTITUTED QUINOLINES | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054445-A1 | Amide Substituted Quinolines | RECQL, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, H1-0 | RAB9A 556/4885NPC1 980/4885ALDH1A1 903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.