⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL450351 | 0.84 | — | — | |
| SCHEMBL2557 | 0.72 | — | — | |
| SCHEMBL2258562 | 0.63 | HSP90AA1 (0.34) | — | |
| SCHEMBL154970 | 0.62 | — | — | |
| SCHEMBL478628 | 0.61 | PDPK1 (0.54) | — | |
| SCHEMBL7579630 | 0.61 | MEN1 (0.44) | — | |
| SCHEMBL23442 | 0.61 | — | — | |
| SCHEMBL131088 | 0.61 | — | — | |
| SCHEMBL207457 | 0.61 | METAP2 (0.38) | — | |
| SCHEMBL206922 | 0.61 | METAP2 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 107 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363874-B1 | TRYPTASE INHIBITORS | ALTANA PHARMA AG (DE) | 2007-06-06 | — | — | EP | claimed |
| EP-1368317-B1 | TRYPTASE INHIBITORS | ALTANA PHARMA AG (DE) | 2006-12-27 | — | — | EP | claimed |
| EP-1401809-B1 | TRYPTASE INHIBITORS | ALTANA PHARMA AG (DE) | 2006-12-20 | — | — | EP | claimed |
| US-7101911-B2 | Tryptase inhibitors | ALTANA PHARMA AG (DE) | 2006-09-05 | — | — | US | claimed |
| US-7060716-B2 | Compound containing two triple bonds | ALTANA PHARMA AG (DE) | 2006-06-13 | — | — | US | claimed |
| US-7015325-B2 | Tryptase inhibitors | ALTANA PHARMA AG (DE) | 2006-03-21 | — | — | US | claimed |
| US-6962941-B2 | Tryptase inhibitors | ALTANA PHARMA AG (DE) | 2005-11-08 | — | — | US | claimed |
| US-6960588-B1 | Tryptase inhibitors | ALTANA PHARMA AG (DE) | 2005-11-01 | — | — | US | claimed |
| US-6924305-B2 | Diazocine derivatives and their use as tryptase inhibitors | ALTANA PHARMA AG (DE) | 2005-08-02 | — | — | US | claimed |
| US-6815557-B2 | Tryptase inhibitors | ALTANA PHARMA AG (DE) | 2004-11-09 | — | — | US | claimed |
| WO-2002074732-A2 | TRYPTASE-INHIBITORS | ALTANA PHARMA AG (DE) | 2002-09-26 | — | — | WO | claimed |
| WO-2002066420-A2 | TRYPTASE INHIBITORS | ALTANA PHARMA AG (DE) | 2002-08-29 | — | — | WO | claimed |
| WO-2002066430-A1 | TRYPTASE INHIBITORS | ALTANA PHARMA AG (DE) | 2002-08-29 | — | — | WO | claimed |
| WO-2002060895-A1 | DIAZOCINE DERIVATIVES AND THEIR USE AS TRYPTASE INHIBITORS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2002-08-08 | — | — | WO | claimed |
| EP-1216236-A1 | TRYPTASE INHIBITORS | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2002-06-26 | — | — | EP | claimed |
| EP-1208089-A2 | DIAZOCIN-DIONE DERIVATIVES AND THEIR USE AS TRYPTASE INHIBITORS | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2002-05-29 | — | — | EP | claimed |
| WO-2001046128-A2 | TRYPTASE INHIBITORS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2001-06-28 | — | — | WO | claimed |
| WO-2001046168-A1 | TRYPTASE INHIBITORS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2001-06-28 | — | — | WO | claimed |
| WO-2001019809-A1 | TRYPTASE INHIBITORS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2001-03-22 | — | — | WO | claimed |
| WO-2001010848-A2 | DIAZOCIN-DIONE DERIVATIVES AND THEIR USE S TRYPTASE INHIBITORS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2001-02-15 | — | — | WO | claimed |