Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of Triaziquone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 3/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | APAF1 | O14727 | 2/20 | 0.33 |
| ▸ | TDP2 | O95551 | 2/20 | 0.33 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triaziquone SCHEMBL17874437 | 0.89 | HTT (0.42) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| Triaziquone SCHEMBL11350903 | 0.89 | HTT (0.42) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| Triaziquone SCHEMBL9791390 | 0.87 | DNMT1 (0.42) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| Triaziquone SCHEMBL21358774 | 0.87 | MAPT (0.43) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| Triaziquone SCHEMBL7783197 | 0.87 | MAPT (0.46) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| Triaziquone SCHEMBL33439 | 0.86 | HTT (0.42) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| Triaziquone SCHEMBL8965684 | 0.85 | HTT (0.39) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| Triaziquone SCHEMBL149876 | 0.83 | MAPT (0.46) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| Triaziquone SCHEMBL6225692 | 0.83 | TP53 (0.38) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| Triaziquone SCHEMBL6000230 | 0.83 | DNMT1 (0.47) | MAPTHTTTP53STAT3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114634886-A | Multifunctional microbial agent capable of degrading various halogenated organic pollutants simultaneously | 河南科技大学 | 2022-06-17 | — | — | CN | claimed |
| CN-114394680-A | Application of microbial agent in degradation of various halogenated organic pollutants | 河南科技大学 | 2022-04-26 | — | — | CN | claimed |
| CN-110038635-B | Acetylene dimerization aqueous phase catalyst and application thereof | 石河子大学 | 2022-02-11 | — | — | CN | claimed |
| CN-111676147-A | Method for enriching and separating dechlorinating tetrachloroethylene bacteria and application | 中山大学 | 2020-09-18 | — | — | CN | claimed |
| CN-111569152-A | Biological valve with anticoagulation and calcification resistance and preparation method thereof | 四川大学 | 2020-08-25 | — | — | CN | claimed |
| CN-110038635-A | A kind of acetylene dimer aqueous phase catalyst and its application | 石河子大学 | 2019-07-23 | — | — | CN | claimed |
| EP-2774630-B1 | METHOD FOR PREPARING EDGE-RIGIDIZED ARTIFICIAL BIOLOGICAL VALVE | SHANGHAI MICROPORT CARDIOFLOW MEDTECH CO LTD (CN) | 2017-07-05 | — | — | EP | claimed |
| EP-2774630-A1 | METHOD FOR PREPARING EDGE-RIGIDIZED ARTIFICIAL BIOLOGICAL VALVE | Shanghai MicroPort Medical (Group) Co., Ltd. (CN) | 2014-09-10 | — | — | EP | claimed |
| CN-118345123-A | Method for producing chemicals by artificial light driven microbial flora in low carbon | 南京工业大学 | 2024-07-16 | — | — | CN | disclosed |
| CN-118324293-A | Carbon-based adsorption/microbial anaerobic degradation risk management and control composite material and application thereof | 浙江大学 | 2024-07-12 | — | — | CN | disclosed |
| CN-112209858-B | Preparation method of 2- [ [ tri (hydroxymethyl) methyl ] amino ] ethanesulfonic acid | 湖南韵邦生物医药有限公司 | 2022-11-01 | — | — | CN | disclosed |
| CN-114806914-A | Yarrowia lipolytica for high yield of beta-carotene and application thereof | 南京工业大学 | 2022-07-29 | — | — | CN | disclosed |
| CN-114634886-A | Multifunctional microbial agent capable of degrading various halogenated organic pollutants simultaneously | 河南科技大学 | 2022-06-17 | — | — | CN | disclosed |
| CN-114394680-A | Application of microbial agent in degradation of various halogenated organic pollutants | 河南科技大学 | 2022-04-26 | — | — | CN | disclosed |
| EP-2774630-B1 | METHOD FOR PREPARING EDGE-RIGIDIZED ARTIFICIAL BIOLOGICAL VALVE | SHANGHAI MICROPORT CARDIOFLOW MEDTECH CO LTD (CN) | 2017-07-05 | — | — | EP | disclosed |
| EP-2774630-A1 | METHOD FOR PREPARING EDGE-RIGIDIZED ARTIFICIAL BIOLOGICAL VALVE | Shanghai MicroPort Medical (Group) Co., Ltd. (CN) | 2014-09-10 | — | — | EP | disclosed |
| WO-2012103385-A2 | BIOCATALYSTS SYNTHESIZING DEREGULATED CELLULASES | QTEROS, INC. (US) | 2012-08-02 | — | — | WO | disclosed |
| WO-2012068537-A2 | NEW BIOCATALYSTS AND PRIMERS FOR PRODUCTION OF CHEMICALS | QTEROS, INC. (US) | 2012-05-24 | — | — | WO | disclosed |
| US-20120064592-A1 | BIOCATALYSTS SYNTHESIZING DEREGULATED CELLULASES | QTEROS, INC. (US) | 2012-03-15 | — | — | US | disclosed |
| WO-2011072264-A2 | METHODS AND COMPOSITIONS FOR BIOMASS TREATMENT | QTEROS, INC. (US) | 2011-06-16 | — | — | WO | disclosed |