Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 2/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4516486 | 1.00 | CREBBP (0.51) | CREBBPPOLBTDP1ALPLNOS1 | |
| SCHEMBL4516489 | 0.80 | CREBBP (0.44) | CREBBPPOLBTDP1ALPLNOS1 | |
| SCHEMBL31129257 | 0.79 | CREBBP (0.61) | CREBBPPOLBTDP1ALPLNOS1 | |
| SCHEMBL9678808 | 0.76 | CREBBP (0.56) | CREBBPPOLBTDP1NOS1KMT2A | |
| SCHEMBL21460047 | 0.75 | NOS1 (0.56) | CREBBPPOLBTDP1ALPLNOS1 | |
| SCHEMBL24430175 | 0.74 | CREBBP (0.52) | CREBBPPOLBTDP1NOS1GRIN2D | |
| SCHEMBL4576197 | 0.73 | MAPT (0.50) | CREBBPNOS1MEN1KMT2AGRIN2D | |
| SCHEMBL4576717 | 0.72 | GRIN2D (0.55) | CREBBPNOS1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL22425024 | 0.72 | NOS1 (0.60) | CREBBPPOLBTDP1ALPLNOS1 | |
| SCHEMBL10876654 | 0.71 | EPHX1 (0.51) | MEN1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090012118-A1 | Kynurenic Acid Amide Derivatives as Nr2b Receptor Antagoni | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2009-01-08 | — | — | US | disclosed |
| EP-1771436-A1 | KYNURENIC ACID AMIDE DERIVATIVES AS NR2B RECEPTOR ANTAGONISTS | Richter Gedeon Vegy Szeti Gy R Rt. (HU) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006010967-A1 | KYNURENIC ACID AMIDE DERIVATIVES AS NR2B RECEPTOR ANTAGONISTS | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012118-A1 | Kynurenic Acid Amide Derivatives as Nr2b Receptor Antagoni | GRIN1, GRIN2A, GRIN2B | CREBBP 2419/4885POLB 3564/4885TDP1 4545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.