SCHEMBL4516565

SCHEMBL4516565

Nc1ccc(C(=O)OCc2ccccc2)cc1N

nearest known ligand 0.64

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.64
TDP1 Q9NUW8 4/20 0.64
SLC6A2 P23975 1/20 0.64
SLC6A3 Q01959 1/20 0.64
LMNA P02545 3/20 0.63
RAB9A P51151 6/20 0.58
ALDH1A1 P00352 4/20 0.58
MAPT P10636 4/20 0.58
NPC1 O15118 4/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
HPGD P15428 2/20 0.55
GAA P10253 1/20 0.50
KDM4E B2RXH2 1/20 0.50
MEN1 O00255 1/20 0.50
HDAC1 Q13547 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.48
LNPEP Q9UIQ6 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8128313 0.88 TDP1 (0.60) KMT2ATDP1SLC6A2SLC6A3LMNA
SCHEMBL23812446 0.88 TDP1 (0.60) KMT2ATDP1SLC6A2SLC6A3LMNA
SCHEMBL8059715 0.88 LMNA (0.64) KMT2ATDP1SLC6A2SLC6A3LMNA
SCHEMBL30306818 0.88 LMNA (0.64) KMT2ATDP1SLC6A2SLC6A3LMNA
SCHEMBL7423041 0.86 KMT2A (0.58) KMT2ATDP1SLC6A2SLC6A3LMNA
SCHEMBL21027553 0.86 TDP1 (0.58) KMT2ATDP1SLC6A2SLC6A3LMNA
SCHEMBL10323667 0.86 TDP1 (0.58) KMT2ATDP1SLC6A2SLC6A3LMNA
SCHEMBL8138317 0.86 KMT2A (0.65) KMT2ATDP1SLC6A2SLC6A3LMNA
SCHEMBL7557781 0.86 TDP1 (0.58) KMT2ATDP1SLC6A2SLC6A3LMNA
SCHEMBL15754802 0.86 KMT2A (0.58) KMT2ATDP1SLC6A2SLC6A3LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023144545-A1 SACCHARIDE SENSING SYSTEMS Carbometrics Limited (GB) 2023-08-03 WO disclosed
US-9815784-B2 CC-1065 analogs and their conjugates SYNTARGA B.V. (NL) 2017-11-14 US disclosed
US-20110207767-A1 Novel cc-1065 Analogs and Their Conjugates BYONDIS B.V. (NL) 2011-08-25 US disclosed
US-7517875-B2 Piperidine derivatives having CCR3 antagonism TEIJIN LIMITED (JP) 2009-04-14 US disclosed
US-20070032525-A1 Piperidine derivatives having ccr3 antagonism TEIJIN LIMITED, A JAPANESE BODY CORPORATE (JP) 2007-02-08 US disclosed
CN-1659161-A Piperidine derivatives having CCR3 antagonism TEIJIN LTD (JP) 2005-08-24 CN disclosed
EP-1502916-A1 PIPERIDINE DERIVATIVES HAVING CCR3 ANTAGONISM TEIJIN LIMITED (JP) 2005-02-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070032525-A1 Piperidine derivatives having ccr3 antagonism CCR3, CCR1, CCR4 KMT2A 3261/4885TDP1 4621/4885SLC6A2 4703/4885
US-20110207767-A1 Novel cc-1065 Analogs and Their Conjugates PCNA, CDC5L, TOP1 KMT2A 1087/4885TDP1 217/4885SLC6A2 810/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.