Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.56 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CACNA2D1 | P54289 | 6/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.43 |
| ▸ | SCN4A | P35499 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27535690 | 0.87 | KCNA3 (0.55) | KCNA3NR3C1LMNACYP1A2CYP2D6 | |
| SCHEMBL29029003 | 0.82 | NR2E1 (0.61) | LMNACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL11144866 | 0.81 | KCNA3 (0.61) | KCNA3NR3C1LMNACYP1A2CYP3A4 | |
| SCHEMBL5449325 | 0.78 | KCNA3 (0.67) | KCNA3NR3C1LMNACYP1A2CYP3A4 | |
| SCHEMBL21917569 | 0.78 | CACNA2D1 (0.50) | KCNA3NR3C1LMNACYP1A2CYP3A4 | |
| SCHEMBL94801 | 0.78 | KCNA3 (0.61) | KCNA3NR3C1LMNACYP1A2CYP3A4 | |
| SCHEMBL14251166 | 0.78 | KCNA3 (0.61) | KCNA3NR3C1LMNACYP1A2CYP3A4 | |
| SCHEMBL4519985 | 0.77 | NR3C1 (0.48) | KCNA3NR3C1LMNACYP1A2CYP3A4 | |
| SCHEMBL10576049 | 0.77 | KCNA3 (0.69) | KCNA3NR3C1LMNACYP1A2CYP3A4 | |
| SCHEMBL14861116 | 0.77 | KCNA3 (0.65) | KCNA3NR3C1LMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090093485-A1 | Novel Sulphonamide Derivatives as Glucocorticoid Receptor Modulators for the Treatment of Inflammatory Diseases | ASTRAZENECA AB (SE) | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093485-A1 | Novel Sulphonamide Derivatives as Glucocorticoid Receptor Modulators for the Treatment of Inflammatory Diseases | NR3C1, NR3C2, NR5A1 | KCNA3 1704/4885NR3C1 1/4885LMNA 4666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.