Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 4/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TNF | P01375 | 3/20 | 0.52 |
| ▸ | NOD2 | Q9HC29 | 3/20 | 0.52 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1263457 | 0.86 | HDAC6 (0.62) | ACACBPOLBTNFNOD2NOD1 | |
| SCHEMBL9950571 | 0.85 | ACACB (0.69) | ACACBPOLBHPGDTNFNOD2 | |
| SCHEMBL3968486 | 0.85 | ACACB (0.69) | ACACBPOLBHPGDTNFNOD2 | |
| Potassium Ion SCHEMBL4527368 | 0.84 | ACACB (0.57) | ACACBPOLBHPGDTNFNOD2 | |
| SCHEMBL1036356 | 0.83 | ACACB (0.63) | ACACBPOLBHPGDTNFNOD2 | |
| SCHEMBL3881820 | 0.82 | ACACB (0.55) | ACACBLMNAHDAC6MEN1KMT2A | |
| SCHEMBL20672151 | 0.81 | TNF (0.64) | ACACBPOLBHPGDTNFNOD2 | |
| SCHEMBL4524637 | 0.80 | ACACB (0.59) | ACACBPOLBHPGDSMN1; SMN2HTT | |
| SCHEMBL1264734 | 0.80 | HDAC6 (0.69) | ACACBHDAC1HDAC6 | |
| SCHEMBL17585155 | 0.79 | ACACB (1.00) | ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099158-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099158-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | HRH3, HRH4, HRH1 | ACACB 3914/4885POLB 4596/4885HPGD 786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.