Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | HTR2B | P41595 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1205833 | 0.90 | ACACB (0.55) | ACACBPOLBHPGDHTR1ADRD4 | |
| Hydrochloric Acid SCHEMBL3095011 | 0.89 | ACACB (0.54) | ACACBPOLBHPGDHTR1ADRD4 | |
| SCHEMBL9950571 | 0.88 | ACACB (0.69) | ACACBPOLBHPGDDRD3ACHE | |
| SCHEMBL4239488 | 0.86 | MEN1 (0.61) | POLBHPGDCHRM2HTR1ACHRM3 | |
| SCHEMBL4517559 | 0.85 | ACACB (0.66) | ACACBPOLBHPGDACHEKDM4E | |
| Benzylamine SCHEMBL8532295 | 0.84 | LOXL2 (0.56) | ACACBHTR1ADRD4HTR2CHTR2B | |
| SCHEMBL1264338 | 0.84 | HDAC6 (0.65) | POLBHPGDKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL20672151 | 0.83 | TNF (0.64) | ACACBPOLBHPGDACHEKDM4E | |
| SCHEMBL1036356 | 0.83 | ACACB (0.63) | ACACBPOLBHPGDACHEKDM4E | |
| SCHEMBL20178679 | 0.83 | ACACB (0.59) | ACACBCHRM2CHRM3KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |