Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.58 |
| ▸ | PRCP | P42785 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4517681 | 0.92 | CYP3A4 (0.67) | CYP3A4CYP2C9CYP1A2CYP2D6NR1I2 | |
| SCHEMBL4980917 | 0.92 | CYP3A4 (0.67) | CYP3A4CYP2C9CYP1A2CYP2D6NR1I2 | |
| SCHEMBL13635774 | 0.91 | CYP3A4 (0.71) | CYP3A4CYP2C9CYP1A2CYP2D6NR1I2 | |
| SCHEMBL12175116 | 0.91 | CYP3A4 (0.71) | CYP3A4CYP2C9CYP1A2CYP2D6NR1I2 | |
| SCHEMBL12159739 | 0.91 | CYP3A4 (0.71) | CYP3A4CYP2C9CYP1A2CYP2D6NR1I2 | |
| SCHEMBL4523640 | 0.88 | CYP3A4 (0.60) | CYP3A4CYP2C9CYP1A2CYP2D6NR1I2 | |
| SCHEMBL4523632 | 0.88 | CYP3A4 (0.60) | CYP3A4CYP2C9CYP1A2CYP2D6NR1I2 | |
| SCHEMBL3343497 | 0.87 | CYP3A4 (0.76) | CYP3A4CYP2C9CYP1A2CYP2D6NR1I2 | |
| SCHEMBL3343491 | 0.87 | CYP3A4 (0.76) | CYP3A4CYP2C9CYP1A2CYP2D6NR1I2 | |
| SCHEMBL1747645 | 0.86 | CYP3A4 (0.62) | CYP3A4CYP2C9CYP1A2CYP2D6NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8303944-B2 | Hepatitis C virus inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-11-06 | — | — | US | disclosed |
| US-20090068140-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090068140-A1 | HEPATITIS C VIRUS INHIBITORS | HAVCR2, PYGL, HCCS | CYP3A4 1107/4885CYP2C9 2585/4885CYP1A2 2139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.