Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 14/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | FABP1 | P07148 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4510754 | 0.95 | AVPR1B (0.54) | AVPR1BKDM4ECYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4505337 | 0.94 | AVPR1B (0.55) | AVPR1BKDM4ECYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4513290 | 0.94 | AVPR1B (0.57) | AVPR1BGAATSHRLMNAFABP1 | |
| SCHEMBL4501396 | 0.92 | AVPR1B (0.66) | AVPR1BCYP3A4ALDH1A1GAATSHR | |
| SCHEMBL4502606 | 0.90 | AVPR1B (0.53) | AVPR1BGAATSHRLMNAFABP1 | |
| SCHEMBL1464844 | 0.88 | AVPR1B (0.51) | AVPR1BALDH1A1GAATSHRLMNA | |
| SCHEMBL74522 | 0.88 | AVPR1B (0.63) | AVPR1BKDM4ECYP3A4HSD17B10ALDH1A1 | |
| SCHEMBL75425 | 0.85 | AVPR1B (0.55) | AVPR1BKDM4ECYP3A4HSD17B10ALDH1A1 | |
| SCHEMBL75454 | 0.85 | AVPR1B (0.48) | AVPR1BKDM4EHSD17B10ALDH1A1TSHR | |
| SCHEMBL75347 | 0.83 | AVPR1B (0.67) | AVPR1BCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8202870-B2 | Substituted oxindole derivatives, medicaments containing the latter and use thereof | ABBOTT GMBH & CO. KG (DE) | 2012-06-19 | — | — | US | claimed |
| US-8202870-B2 | Substituted oxindole derivatives, medicaments containing the latter and use thereof | ABBOTT GMBH & CO. KG (DE) | 2012-06-19 | — | — | US | disclosed |
| US-20090215790-A1 | Substituted Oxindole Derivatives, Medicaments Containing the Latter and Use Thereof | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215790-A1 | Substituted Oxindole Derivatives, Medicaments Containing the Latter and Use Thereof | OXTR, AVPR2, AVPR1B | AVPR1B 3/4885KDM4E 4326/4885CYP1A2 1037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.