SCHEMBL4522429

SCHEMBL4522429

COc1ccc(N2CCN(Cc3nc(-c4ccc(C(F)(F)F)cc4)sc3CCC(=O)c3ccc(OC(C)C(=O)O)c(C)c3)CC2)cc1

nearest known ligand 0.49

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 13/20 0.49
PPARA Q07869 11/20 0.49
CETP P11597 1/20 0.40
POLB P06746 1/20 0.40
HTR1A P08908 1/20 0.39
PPARG P37231 4/20 0.39
MAPT P10636 1/20 0.39
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4511038 0.94 PPARD (0.42) PPARDPPARACETPPOLBHTR1A
SCHEMBL4502832 0.89 PPARD (0.53) PPARDPPARAPPARG
SCHEMBL4509002 0.89 PPARD (0.58) PPARDPPARAPPARG
SCHEMBL4498481 0.88 POLB (0.44) PPARDPPARACETPPOLBPPARG
SCHEMBL4801990 0.87 PPARD (0.56) PPARDPPARAHTR1APPARGMAPT
SCHEMBL4801366 0.87 PPARD (0.56) PPARDPPARAHTR1APPARGMAPT
SCHEMBL4803214 0.87 PPARD (0.56) PPARDPPARAHTR1APPARGMAPT
SCHEMBL4508937 0.86 PPARA (0.55) PPARDPPARAPPARG
SCHEMBL4522466 0.86 PPARD (0.44) PPARDPPARACETPPOLBPPARG
SCHEMBL4503622 0.86 PPARD (0.49) PPARDPPARACETPPOLBPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090203908-A1 Activator for Peroxisome Proliferator-Activated Receptor NIPPON CHEMIPHAR CO., LTD. (JP) 2009-08-13 US disclosed
EP-1897872-A1 ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR Nippon Chemiphar Co., Ltd. (JP) 2008-03-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090203908-A1 Activator for Peroxisome Proliferator-Activated Receptor PPARA, PPARG, PPARD PPARD 3/4885PPARA 1/4885CETP 1172/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.