SCHEMBL4498481

SCHEMBL4498481

COc1ccc(N2CCN(Cc3nc(-c4ccc(C(F)(F)F)cc4)sc3CCC(=O)c3ccc(O)c(C)c3)CC2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.44
CETP P11597 1/20 0.43
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
PPARD Q03181 5/20 0.41
PPARA Q07869 5/20 0.41
P4HB P07237 1/20 0.41
TP53 P04637 1/20 0.41
THRB P10828 1/20 0.41
PPARG P37231 2/20 0.40
STAT3 P40763 1/20 0.40
SOD1 P00441 1/20 0.40
GAA P10253 1/20 0.39
MAPT P10636 1/20 0.39
TSHR P16473 1/20 0.39
HTT P42858 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
HDAC1 Q13547 1/20 0.39
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4515600 0.95 CETP (0.46) CETPMEN1KMT2APPARDPPARA
SCHEMBL4522410 0.94 PPARD (0.44) POLBCETPMEN1KMT2APPARD
SCHEMBL4523435 0.94 STAT3 (0.46) MEN1KMT2APPARDPPARATP53
SCHEMBL4516952 0.94 CETP (0.43) CETPMEN1KMT2APPARDPPARA
SCHEMBL4521400 0.93 CETP (0.44) POLBCETPPPARDPPARASTAT3
SCHEMBL4517041 0.93 CETP (0.41) POLBCETPPPARDPPARATP53
SCHEMBL4523286 0.93 CACNA1G (0.42) POLBCETPMEN1KMT2ATP53
SCHEMBL4501707 0.93 CETP (0.44) CETPPPARDPPARATP53MAPT
SCHEMBL4520889 0.92 MAPT (0.46) POLBCETPMEN1KMT2APPARD
SCHEMBL4502243 0.92 PRKAA2 (0.48) MEN1KMT2ASTAT3MAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090203908-A1 Activator for Peroxisome Proliferator-Activated Receptor NIPPON CHEMIPHAR CO., LTD. (JP) 2009-08-13 US disclosed
EP-1897872-A1 ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR Nippon Chemiphar Co., Ltd. (JP) 2008-03-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090203908-A1 Activator for Peroxisome Proliferator-Activated Receptor PPARA, PPARG, PPARD POLB 1527/4885CETP 1172/4885MEN1 4878/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.