Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GNAO1 | P09471 | 6/20 | 0.41 |
| ▸ | GNAI3 | P08754 | 5/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SOD3 | P08294 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11717124 | 0.97 | POLB (0.46) | POLBSMN1; SMN2CXCR4HSD17B10GNAO1 | |
| SCHEMBL178388 | 0.97 | — | — | |
| SCHEMBL6927442 | 0.97 | — | — | |
| SCHEMBL3971660 | 0.95 | CXCR4 (0.52) | POLBSMN1; SMN2CXCR4HSD17B10GNAO1 | |
| Hydrochloric Acid SCHEMBL1318698 | 0.95 | POLB (0.48) | POLBSMN1; SMN2CXCR4HSD17B10GNAO1 | |
| Hydrochloric Acid SCHEMBL1578109 | 0.95 | POLB (0.48) | POLBSMN1; SMN2CXCR4HSD17B10GNAO1 | |
| Ammonia Solution, Strong SCHEMBL238025 | 0.95 | POLB (0.48) | POLBSMN1; SMN2CXCR4HSD17B10GNAO1 | |
| Methylamine SCHEMBL928302 | 0.92 | POLB (0.46) | POLBSMN1; SMN2CXCR4HSD17B10GNAO1 | |
| Hydrochloric Acid SCHEMBL28781885 | 0.92 | POLB (0.46) | POLBSMN1; SMN2CXCR4HSD17B10GNAO1 | |
| Dimethylamine SCHEMBL4062959 | 0.90 | POLB (0.45) | POLBSMN1; SMN2CXCR4HSD17B10GNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 330 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267660-A1 | CONDENSATION CURABLE COMPOSITION COMPRISING SILOXANE-IMIDE BASE POLYMER | Momentive Performance Materials Inc. (US) | 2023-11-01 | — | — | EP | claimed |
| WO-2022140006-A1 | CONDENSATION CURABLE COMPOSITION COMPRISING SILOXANE-IMIDE BASE POLYMER | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2022-06-30 | — | — | WO | claimed |
| US-20220195125-A1 | CONDENSATION CURABLE COMPOSITION COMPRISING SILOXANE-IMIDE BASE POLYMER | MOMENTIVE PERFORMANCE MATERIALS INC. | 2022-06-23 | — | — | US | claimed |
| EP-3891222-A1 | ELECTROSTATICALLY DISSIPATIVE ROOM TEMPERATURE VULCANIZABLE SILICONE | Momentive Performance Materials Inc. (US) | 2021-10-13 | — | — | EP | claimed |
| EP-3039068-B1 | MOISTURE CURABLE COMPOUND WITH AMINO ACIDS | MOMENTIVE PERFORMANCE MAT INC (US) | 2020-12-16 | — | — | EP | claimed |
| EP-3074450-B1 | MOISTURE CURABLE COMPOUND WITH METAL-ARENE COMPLEXES | MOMENTIVE PERFORMANCE MAT INC (US) | 2020-11-11 | — | — | EP | claimed |
| WO-2020117719-A1 | ELECTROSTATICALLY DISSIPATIVE ROOM TEMPERATURE VULCANIZABLE SILICONE | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2020-06-11 | — | — | WO | claimed |
| US-10174169-B2 | Moisture curable compound with metal-arene complexes | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2019-01-08 | — | — | US | claimed |
| EP-3262128-B1 | CURABLE SILOXANE COMPOSITIONS | MOMENTIVE PERFORMANCE MAT INC (US) | 2018-11-21 | — | — | EP | claimed |
| US-10023699-B2 | Curable siloxane compositions | MOMENTIVE PERFORMANCE MATERIALS, INC. (US) | 2018-07-17 | — | — | US | claimed |
| EP-2614107-A1 | MOISTURE CURABLE ORGANOPOLYSILOXANE COMPOSITION | Momentive Performance Materials Inc. (US) | 2013-07-17 | — | — | EP | claimed |
| WO-2013101751-A1 | MOISTURE CURABLE ORGANOPOLYSILOXANE COMPOSITION | MOMENTIVE PERFORMANCE MATERIALS, INC. (US) | 2013-07-04 | — | — | WO | claimed |
| WO-2013101755-A1 | MOISTURE CURABLE ORGANOPOLYSILOXANE COMPOSITION | MOMENTIVE PERFORMANCE MATERIALS, INC. (US) | 2013-07-04 | — | — | WO | claimed |
| WO-2013090127-A1 | MOISTURE CURABLE ORGANOPOLYSILOXANE COMPOSITIONS | MOMENTIVE PERFORMANCE MATERIALS, INC. (US) | 2013-06-20 | — | — | WO | claimed |
| WO-2013090132-A2 | MOISTURE CURABLE ORGANOPOLYSILOXANE COMPOSITIONS | MOMENTIVE PERFORMANCE MATERIALS, INC. (US) | 2013-06-20 | — | — | WO | claimed |
| WO-2013071078-A1 | MOISTURE CURABLE ORGANOPOLYSILOXANE COMPOSITION | MOMENTIVE PERFORMANCE MATERIALS, INC. (US) | 2013-05-16 | — | — | WO | claimed |
| WO-2013070227-A1 | MOISTURE CURABLE COMPOSITION OF A POLYMER HAVING SILYL GROUPS | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2013-05-16 | — | — | WO | claimed |
| US-20120065308-A1 | MOISTURE CURABLE ORGANOPOLYSILOXANE COMPOSITION | MOMENTIVE PERFORMANCE MATERIALS INC. | 2012-03-15 | — | — | US | claimed |
| WO-2012033886-A1 | MOISTURE CURABLE ORGANOPOLYSILOXANE COMPOSITION | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2012-03-15 | — | — | WO | claimed |
| EP-0091511-A2 | 1-(3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl)-4-(substituted)-piperazines and -piperidines, a process for the preparation thereof, pharmaceutical compositions containing the same and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-10-19 | — | — | EP | claimed |