Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4522759 | 1.00 | NPC1 (0.56) | NPC1RAB9AL3MBTL1NOTUMTMEM97 | |
| SCHEMBL4434984 | 0.76 | NPC1 (0.53) | NPC1RAB9AL3MBTL1NOTUMTMEM97 | |
| SCHEMBL27589588 | 0.75 | NPC1 (0.52) | NPC1RAB9AL3MBTL1NOTUMTMEM97 | |
| SCHEMBL630773 | 0.74 | MEN1 (0.49) | NPC1RAB9AL3MBTL1P2RX4SMN1; SMN2 | |
| SCHEMBL7245273 | 0.74 | MEN1 (0.49) | NPC1RAB9AL3MBTL1P2RX4SMN1; SMN2 | |
| SCHEMBL7264096 | 0.73 | HTR2C (0.47) | NPC1RAB9AL3MBTL1P2RX4SMN1; SMN2 | |
| SCHEMBL6001297 | 0.73 | HTR2C (0.47) | NPC1RAB9AL3MBTL1P2RX4SMN1; SMN2 | |
| SCHEMBL542153 | 0.73 | HTR2C (0.49) | NPC1RAB9AL3MBTL1P2RX4SMN1; SMN2 | |
| SCHEMBL542152 | 0.73 | HTR2C (0.49) | NPC1RAB9AL3MBTL1P2RX4SMN1; SMN2 | |
| SCHEMBL1834783 | 0.73 | HTR2C (0.49) | NPC1RAB9AL3MBTL1P2RX4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090238761-A1 | Novel Aryl Piperazine Derivatives With Medical Utility | UNIVERSITA DEGLI STUDI DI SIENA (IT) | 2009-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090238761-A1 | Novel Aryl Piperazine Derivatives With Medical Utility | HTR2C, HTR2A, DRD2 | NPC1 3391/4885RAB9A 2613/4885L3MBTL1 3890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.