Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | ACACB | O00763 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.47 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.47 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.47 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4505609 | 0.96 | HRH3 (0.55) | HRH3ALDH1A1HPGDSIGMAR1ACACB | |
| SCHEMBL4520566 | 0.89 | HRH3 (0.58) | HRH3ALDH1A1HPGDMBTD1L3MBTL3 | |
| SCHEMBL13895352 | 0.88 | HRH3 (0.57) | HRH3ALDH1A1HPGDACACBMBTD1 | |
| SCHEMBL4436467 | 0.88 | ALDH1A1 (0.57) | HRH3ALDH1A1HPGDMBTD1L3MBTL3 | |
| SCHEMBL4436601 | 0.86 | HRH3 (0.57) | HRH3ALDH1A1HPGDMBTD1L3MBTL3 | |
| SCHEMBL4439293 | 0.85 | HRH3 (0.54) | HRH3ALDH1A1HPGDMBTD1L3MBTL3 | |
| SCHEMBL4528393 | 0.84 | HRH3 (0.56) | HRH3ALDH1A1HPGDACACBMBTD1 | |
| SCHEMBL4432955 | 0.84 | ALDH1A1 (0.57) | HRH3ALDH1A1HPGDSIGMAR1MBTD1 | |
| SCHEMBL4524637 | 0.83 | ACACB (0.59) | HRH3ALDH1A1HPGDSIGMAR1ACACB | |
| SCHEMBL4428046 | 0.82 | HRH3 (0.50) | HRH3ALDH1A1HPGDMBTD1L3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099158-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-16 | — | — | US | claimed |
| US-20090099158-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-16 | — | — | US | disclosed |
| US-20090099158-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-16 | — | — | US | disclosed |
| US-20090099158-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-16 | — | — | US | disclosed |
| WO-2008109336-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099158-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | HRH3, HRH4, HRH1 | HRH3 1/4885ALDH1A1 3918/4885HPGD 786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.