Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.42 |
| ▸ | MTOR | P42345 | 10/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.37 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.37 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3760177 | 0.85 | NPC1 (0.41) | PIK3CAALDH1A1TLR8NPC1MAPK1 | |
| SCHEMBL4525197 | 0.84 | ALDH1A1 (0.52) | ALDH1A1GAATLR8NPC1MAPK1 | |
| SCHEMBL4102271 | 0.81 | PIK3CA (0.42) | PIK3CAMTORCYP2A6PDGFRBPDGFRA | |
| SCHEMBL4122691 | 0.80 | MAP4K4 (0.55) | ALDH1A1TLR8NPC1MAPK1RAB9A | |
| SCHEMBL823753 | 0.80 | MAP4K4 (0.48) | ALDH1A1NPC1MAPK1RAB9AMAP4K4 | |
| SCHEMBL4533771 | 0.79 | MAP4K4 (0.39) | ALDH1A1NPC1MAPK1RAB9AMAP4K4 | |
| SCHEMBL823714 | 0.79 | MAPT (0.40) | ALDH1A1NPC1MAPK1RAB9AMAP4K4 | |
| SCHEMBL4536473 | 0.79 | MAP4K4 (0.49) | ALDH1A1GAANPC1MAPK1RAB9A | |
| SCHEMBL4528297 | 0.78 | MAP4K4 (0.49) | ALDH1A1NPC1MAPK1RAB9AMAP4K4 | |
| SCHEMBL4537635 | 0.78 | MAP4K4 (0.46) | MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232278-B2 | Pyrido(3,2-D)pyrimidines and pharmaceutical compositions useful for treating hepatitis C | GILEAD SCIENCES, INC. (US) | 2012-07-31 | — | — | US | claimed |
| US-20090131414-A1 | PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING HEPATITIS C | GILEAD SCIENCES, INC. (US) | 2009-05-21 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131414-A1 | PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING HEPATITIS C | DPYD, TYMP, PNPO | PIK3CA 609/4885MTOR 4361/4885ALDH1A1 1010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.