Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | NT5E | P21589 | 1/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4517367 | 0.99 | KMT2A (0.61) | KMT2ANT5EROCK2ROCK1MAPK1 | |
| SCHEMBL4521216 | 0.90 | ROCK2 (0.55) | KMT2ANT5EROCK2ROCK1MEN1 | |
| SCHEMBL4517023 | 0.89 | ROCK2 (0.61) | KMT2ANT5EROCK2ROCK1MEN1 | |
| Hydrochloric Acid SCHEMBL4762964 | 0.89 | ROCK2 (0.54) | KMT2ANT5EROCK2ROCK1MEN1 | |
| Hydrochloric Acid SCHEMBL4511190 | 0.88 | ROCK2 (0.62) | KMT2ANT5EROCK2ROCK1MEN1 | |
| SCHEMBL4527192 | 0.86 | KDM4E (0.64) | KMT2AROCK2ROCK1MAPK1MEN1 | |
| Hydrochloric Acid SCHEMBL4511323 | 0.85 | KDM4E (0.63) | KMT2AROCK2ROCK1MAPK1MEN1 | |
| SCHEMBL4521062 | 0.85 | ROCK2 (0.80) | KMT2ANT5EROCK2ROCK1MAPK1 | |
| Hydrochloric Acid SCHEMBL4517331 | 0.84 | ROCK2 (0.78) | KMT2ANT5EROCK2ROCK1MAPK1 | |
| SCHEMBL1553702 | 0.84 | KMT2A (0.66) | KMT2ANT5EROCK2ROCK1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233960-A1 | Kinase Inhibitors | DEVGEN NV (BE) | 2009-09-17 | — | — | US | claimed |
| CN-101287707-A | Kinase inhibitors | DEVGEN NV (BE) | 2008-10-15 | — | — | CN | claimed |
| EP-1934181-A2 | KINASE INHIBITORS | Devgen NV (BE) | 2008-06-25 | — | — | EP | claimed |
| WO-2007042321-A2 | KINASE INHIBITORS | DEVGEN N.V. (BE) | 2007-04-19 | — | — | WO | claimed |
| US-20090233960-A1 | Kinase Inhibitors | DEVGEN NV (BE) | 2009-09-17 | — | — | US | disclosed |
| US-20090233960-A1 | Kinase Inhibitors | DEVGEN NV (BE) | 2009-09-17 | — | — | US | disclosed |
| CN-101287707-A | Kinase inhibitors | DEVGEN NV (BE) | 2008-10-15 | — | — | CN | disclosed |
| WO-2007042321-A2 | KINASE INHIBITORS | DEVGEN N.V. (BE) | 2007-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233960-A1 | Kinase Inhibitors | ROCK1, MAP3K1, MAP3K11 | KMT2A 3194/4885NT5E 4665/4885ROCK2 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.