Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.54 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1874970 | 0.90 | MAPK14 (0.67) | MAPK14PRKACAROCK1ROCK2MAPK9 | |
| SCHEMBL4337023 | 0.89 | MAPK14 (0.61) | MAPK14PRKACAROCK1ROCK2RIPK3 | |
| SCHEMBL4332759 | 0.84 | MAPK14 (0.61) | MAPK14MAPK9MAPK10MAPK11HSP90AA1 | |
| SCHEMBL4465470 | 0.84 | MAPK14 (0.64) | MAPK14MAPK9MAPK10MAPK11 | |
| SCHEMBL4341320 | 0.84 | MAPK14 (0.61) | MAPK14ROCK2MAPK9MAPK10MAPK11 | |
| SCHEMBL4339299 | 0.83 | MAPK14 (0.60) | MAPK14MAPK9MAPK10MAPK11HSP90AA1 | |
| SCHEMBL4342438 | 0.83 | MAPK14 (0.60) | MAPK14MAPK9MAPK10MAPK11HSP90AA1 | |
| SCHEMBL4336216 | 0.83 | MAPK14 (0.59) | MAPK14ROCK2MAPK9MAPK10MAPK11 | |
| SCHEMBL4343996 | 0.83 | MAPK14 (0.61) | MAPK14PRKACAROCK1MAPK9MAPK10 | |
| SCHEMBL4337029 | 0.81 | MAPK14 (0.57) | MAPK14ROCK1ROCK2MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8207203-B2 | Pyridylisoxazole derivatives | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-06-26 | — | — | US | disclosed |
| US-20090306145-A1 | Pyridylisoxazole Derivatives | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306145-A1 | Pyridylisoxazole Derivatives | CNKSR1, MAPK1, MAPK3 | MAPK14 43/4885PRKACA 118/4885ROCK1 355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.