Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NT5E | P21589 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14547284 | 1.00 | ROCK2 (0.54) | ROCK2ROCK1HDAC1HDAC3NAMPT | |
| Hydrochloric Acid SCHEMBL4519823 | 0.99 | ROCK2 (0.53) | ROCK2ROCK1HDAC1HDAC3NAMPT | |
| SCHEMBL4517023 | 0.85 | ROCK2 (0.61) | ROCK2ROCK1HDAC1NAMPTKDM4E | |
| Hydrochloric Acid SCHEMBL4511190 | 0.84 | ROCK2 (0.62) | ROCK2ROCK1HDAC1NAMPTKDM4E | |
| SCHEMBL4527276 | 0.84 | ROCK2 (0.51) | ROCK2ROCK1KDM4ENPC1RAB9A | |
| SCHEMBL4519239 | 0.84 | ROCK2 (0.57) | ROCK2ROCK1NAMPTKDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL4513943 | 0.83 | ROCK2 (0.50) | ROCK2ROCK1KDM4ENPC1RAB9A | |
| Hydrochloric Acid SCHEMBL4515980 | 0.83 | ROCK2 (0.56) | ROCK2ROCK1NAMPTKDM4ENPC1 | |
| SCHEMBL4525420 | 0.82 | ROCK2 (0.55) | ROCK2ROCK1NAMPTKDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL4513491 | 0.81 | ROCK2 (0.54) | ROCK2ROCK1NAMPTKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233960-A1 | Kinase Inhibitors | DEVGEN NV (BE) | 2009-09-17 | — | — | US | claimed |
| CN-101287707-A | Kinase inhibitors | DEVGEN NV (BE) | 2008-10-15 | — | — | CN | claimed |
| EP-1934181-A2 | KINASE INHIBITORS | Devgen NV (BE) | 2008-06-25 | — | — | EP | claimed |
| WO-2007042321-A2 | KINASE INHIBITORS | DEVGEN N.V. (BE) | 2007-04-19 | — | — | WO | claimed |
| US-20090233960-A1 | Kinase Inhibitors | DEVGEN NV (BE) | 2009-09-17 | — | — | US | disclosed |
| US-20090233960-A1 | Kinase Inhibitors | DEVGEN NV (BE) | 2009-09-17 | — | — | US | disclosed |
| US-20090233960-A1 | Kinase Inhibitors | DEVGEN NV (BE) | 2009-09-17 | — | — | US | disclosed |
| CN-101287707-A | Kinase inhibitors | DEVGEN NV (BE) | 2008-10-15 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233960-A1 | Kinase Inhibitors | ROCK1, MAP3K1, MAP3K11 | ROCK2 32/4885ROCK1 1/4885HDAC1 1208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.