Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9292504 | 0.76 | NPC1 (0.40) | MAPTRAB9ANPC1 | |
| SCHEMBL3610805 | 0.73 | ALDH1A1 (0.45) | KDM4EMAPTLMNASMN1; SMN2RAB9A | |
| SCHEMBL9293445 | 0.70 | NPC1 (0.42) | MAPTRAB9ANPC1 | |
| SCHEMBL3612577 | 0.68 | MAPT (0.43) | KDM4EMAPTLMNASMN1; SMN2RAB9A | |
| SCHEMBL3602005 | 0.66 | KMT2A (0.43) | KDM4EMAPTLMNASMN1; SMN2RAB9A | |
| SCHEMBL9293390 | 0.65 | MAPT (0.62) | KDM4EMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9293439 | 0.65 | MAPT (0.43) | MAPTRAB9ANPC1 | |
| SCHEMBL9368118 | 0.65 | MAPT (0.38) | KDM4EMAPTSMN1; SMN2RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL10730733 | 0.65 | MAPT (0.61) | KDM4EMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9271973 | 0.64 | HRH2 (0.41) | KDM4EMAPTRAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010508-A1 | THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120096-A1 | THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |