⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2008537 | 0.83 | KCNH2 (0.32) | — | |
| SCHEMBL6238419 | 0.81 | JAK2 (0.33) | — | |
| SCHEMBL8217123 | 0.81 | KMT2A (0.33) | — | |
| SCHEMBL293745 | 0.78 | KCNA3 (0.34) | — | |
| SCHEMBL584941 | 0.77 | — | — | |
| SCHEMBL9031950 | 0.77 | — | — | |
| SCHEMBL5253475 | 0.77 | — | — | |
| SCHEMBL1006142 | 0.77 | — | — | |
| SCHEMBL526347 | 0.77 | — | — | |
| SCHEMBL49802 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 242 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023178285-A1 | TRICYCLIC UREA COMPOUNDS AS JAK2 V617F INHIBITORS | INCYTE CORPORATION (US) | 2023-09-21 | — | — | WO | claimed |
| US-20230295124-A1 | TRICYCLIC UREA COMPOUNDS AS JAK2 V617F INHIBITORS | INCYTE CORPORATION | 2023-09-21 | — | — | US | claimed |
| US-20220009882-A1 | ORGANOSULFUR COMPOUNDS | MARIPOSA THERAPEUTICS LTD. (GB) | 2022-01-13 | — | — | US | claimed |
| EP-3877362-A1 | ORGANOSULFUR COMPOUNDS | Mariposa Therapeutics Ltd. (GB) | 2021-09-15 | — | — | EP | claimed |
| CN-113166047-A | Organic sulfur compound | 马里波萨治疗有限公司 | 2021-07-23 | — | — | CN | claimed |
| EP-2951179-B1 | SPIRO-QUINAZOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROLOGICAL DISEASES AND CONDITIONS | MERCK PATENT GMBH (DE) | 2020-03-11 | — | — | EP | claimed |
| US-9862691-B2 | Cyclic triazo and diazo sodium channel blockers | UNIVERSITY OF GREENWICH (GB) | 2018-01-09 | — | — | US | claimed |
| US-9708321-B2 | Spiro-quinazolinone derivatives and their use as positive allosteric modulators of mGluR4 | MERCK PATENT GMBH (DE) | 2017-07-18 | — | — | US | claimed |
| US-20160311784-A1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | UNIVERSITY OF GREENWICH (GB) | 2016-10-27 | — | — | US | claimed |
| US-20150361079-A1 | Spiro-Quinazolinone Derivatives and their Use as Positive Allosteric Modulators of mGluR4 | MERCK PATENT GMBH (DE) | 2015-12-17 | — | — | US | claimed |
| WO-2007149873-A2 | KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2007-12-27 | — | — | WO | claimed |
| US-20070299072-A1 | KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2007-12-27 | — | — | US | claimed |
| US-20070111995-A1 | Pyrazolo [3,4-B] pyridine Compounds and Their Use as Phosphodiesterase Inhibitors | GLAXO GROUP LIMITED (GB) | 2007-05-17 | — | — | US | claimed |
| WO-2003006015-A1 | SUBSTITUTED THIAZOLES AND OXAZOLES AS CORTICOTROPIN RELEASING HORMONE LIGANDS | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2003-01-23 | — | — | WO | claimed |
| EP-0643695-B1 | FUNGICIDAL INDOLE DERIVATIVES | SHELL INT RESEARCH (NL) | 1996-08-14 | — | — | EP | claimed |
| EP-0711290-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1996-05-15 | — | — | EP | claimed |
| EP-0643695-A1 | FUNGICIDAL INDOLE DERIVATIVES. | SHELL INT RESEARCH (NL) | 1995-03-22 | — | — | EP | claimed |
| US-5399559-A | Control of phytopathogens | SHELL RESEARCH LIMITED (GB) | 1995-03-21 | — | — | US | claimed |
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | claimed |
| WO-1993025524-A1 | FUNGICIDAL INDOLE DERIVATIVES | SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) | 1993-12-23 | — | — | WO | claimed |