⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4525843 | 0.98 | — | — | |
| SCHEMBL20742424 | 0.86 | — | — | |
| SCHEMBL3204554 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL717963 | 0.79 | — | — | |
| SCHEMBL21449654 | 0.76 | TSHR (0.37) | — | |
| SCHEMBL909692 | 0.75 | NOS2 (0.42) | — | |
| Hydrochloric Acid SCHEMBL20819822 | 0.75 | NOS2 (0.42) | — | |
| Hydrochloric Acid SCHEMBL14333624 | 0.74 | TSHR (0.36) | — | |
| Hydrochloric Acid SCHEMBL4532413 | 0.73 | NOS2 (0.40) | — | |
| SCHEMBL18652824 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8314121-B2 | Imidazolone derivatives, preparation thereof as drugs, pharmaceutical compositions, and use thereof as protein kinase inhibitors, in particular CDC7 | SANOFI (FR) | 2012-11-20 | — | — | US | disclosed |
| US-20090253679-A1 | NEW IMIDAZOLONE DERIVATIVES, PREPARATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS PROTEIN KINASE INHIBITORS, IN PARTICULAR CDC7 | SANOFI-AVENTIS (FR) | 2009-10-08 | — | — | US | disclosed |